高良姜醇提乙酸乙酯萃取物对异嗜高岭土模型大鼠的止呕作用  

Antiemetic Effect of Ethyl Acetate Extract with Ethanol Extraction of Galangal in Allotriophagic Kaolin-induced Model Rats

作　　者：刘洋[1] 苏东勤 张颖[1] Liu Yang Su Dongqin Zhang Ying(Department of Pharmacy, No. 205 Hospital of PLA, Liaoning Jinzhou 121001, China)

机构地区：[1]解放军第205医院药剂科,辽宁锦州121001

出　　处：《中国药师》2017年第6期1020-1022,1034,共4页China Pharmacist

摘　　要：目的:研究高良姜醇提乙酸乙酯萃取物(以下简称高良姜提取物)对异嗜高岭土模型大鼠的止呕作用。方法:大鼠分别给予化学药物顺铂、阿扑吗啡和接受旋转刺激,建立大鼠3种异嗜高岭土模型,以阿扑吗啡、昂丹司琼和甲氧氯普胺作为对照药物。将实验大鼠分为高良姜提取物低、中、高3个剂量组,给予高良姜提取物预防性用药,观察给药后对模型大鼠的止呕作用。结果:化学药物顺铂(3.0 mg·kg^(-1),ip)、阿扑吗啡(3.2 mg·kg^(-1),ih)及旋转刺激(离心力3.4×g,60min)均可以引起大鼠的异嗜呕吐行为。高良姜提取物低(1 500 mg·kg^(-1))、中(4 500 mg·kg^(-1))、高(9 000 mg·kg^(-1))剂量,均未能有效抑制顺铂、阿扑吗啡及旋转所致的大鼠异嗜高岭土行为(P>0.05)。结论:高良姜提取物不能有效抑制异嗜高岭土模型大鼠的呕吐行为,可能其药理作用与P物质、5-羟色胺、多巴胺及抑制化学呕吐感受区不存在关联。Objective ： To study the antiemetic effect of the ethyl acetate extract with ethanol extraction of Galangal （ hereinafter re- ferred to as galangal extract） in allotriophagic Kaolin model rats. Methods： The rats were administered respectively with chemical drug cisplatin and apomorphine, and received the rotation stimulation as well. Three types of allotriophagic Kaolin models were established, and apomorphine, ondansetron and metoclopramide were used as the control drugs. The experimental rats were divided into 3 groups at low, medium and high dose of Galangal extract with prophylactic effect. The antiemetic effect was observed after the treatment. Re- sults： Chemical drug cisplatin （3.0 mg·kg-1, intraperitoneal injection） and apomorphine （3.2 mg· kg - 1, subcutaneous injection） and the rotation stimulation （centrifugal force of 3.4 x g,60min） could induce allotriophagic vomiting in rats. The galangal extract at low （ l 500 mg·kg-1 ）, medium （4 500 mg·kg-1） and high （9 000 mg·kg- l ） dose all fail to effectively inhibit tile allotriophagic Kaolin behavior of rats caused by cisplatin, apomorphine and rotation（P 〉0.05）. Conclusion： Galangal extract can not effectively in- hibit the vomiting of allotriophagic Kaolin model rats. Probably, there is no correlation between the pharmacological effects of galangal extract and substance P, 5-hydroxytryptamine, dopamine as well as receptive zone of chemical Vomiting inhibition.

关 键 词：高良姜提取物 止呕 P物质 5-羟色胺 多巴胺 

分 类 号：R285.5[医药卫生—中药学]