喜炎平注射液与7种抗菌药物联用的体外抗菌活性研究  

Antibacterial Activity in vitro of Xiyanping Injection Combined with 7 Kinds of Antibiotics

作　　者：李巧如[1] 张鹏[1] 吴媛媛[2] 马娟[3] 王晓雯[1] 贺玫[1] Li Qiaoru Zhang Peng Wu Yuanyuan Ma Juan Wang Xiaowen He Mei(Department of Pharmacy, Shaanxi Provicial Peo- ple＇s Hospital, Xi＇ an 710068, China School of Pharmacy, Xi＇ an Medical College Department of Clinical Laboratory, Shaanxi Provicial People＇ s Hospital)

机构地区：[1]陕西省人民医院药学部,西安710068 [2]西安医学院药学院 [3]陕西省人民医院检验科

出　　处：《中国药师》2017年第6期1136-1138,共3页China Pharmacist

摘　　要：目的:研究喜炎平注射液分别与头孢西丁、头孢呋辛、头孢甲肟、头孢曲松、阿米卡星、左氧氟沙星、美罗培南7种抗菌药物联合使用对金黄色葡萄球菌、大肠埃希菌、肺炎克雷伯杆菌、铜绿假单胞菌、鲍曼不动杆菌的标准菌株和临床分离菌株的体外抗菌活性。方法:采用微量琼脂稀释法和棋盘法,应用96孔平板分别测定喜炎平注射液与头孢西丁等7种抗菌药物在体外单独使用以及联合应用对各类细菌的最低抑菌浓度(MIC),并计算联合药敏指数(FICI),从而评价喜炎平注射液与7种抗菌药物联合应用的体外抗菌活性。结果:喜炎平注射液与头孢西丁联合使用对大肠埃希菌的MIC等于抗菌药物单独使用的MIC;与左氧氟沙星联合使用对肺炎克雷伯杆菌的MIC等于抗菌药物单独使用的MIC,与其他抗菌药物联合使用的MIC均大于单独使用的MIC。结论:喜炎平注射液与头孢西丁等7种抗菌药物联合使用对金黄色抗菌球菌、大肠埃希菌、肠炎克雷伯菌的抗菌使用表现,为据抗或无关。Objective： To study the antibacterial activity in vitro of Xiyanping injection combined with cefoxitin, cefuroxime, ceftriaxone, cefmenoxime, amikacin, levofloxacin and meropenem against staphylococcus aureus, escherichia coli, klebsiella pneumoni- ae, pseudomonas aeruginosa and acinetobacter bauman. Methods ： Minimum inhibitory concentration （MIC） of the 7 kinds of antimi- crobial agents used individually or combined with Xiyanping injection on germs were determined respectively on 96 plates by using the agar dilution method and the checkerboard method. Fractional inhibitory concentration index （FICI） was calculated to evaluate the an- tibacterial activity of Xiyanping injection combined with the 7 kinds of antimicrobial agents in vitro. Results ： MIC of Xiyanping injec- tion combined with cefoxitin was the same as that of cefoxitin used individually on escherichia coli. MIC of levofloxacin combined with Xiyanping injection showed no difference with that of leofloxacin used individually on klebsiella pneumoniae. Besides, Xiyanping injec- tion could increase the MIC of the other antimicrobial agents on germs. Conclusion： Xiyanping injection combined with antimicrobial agents on staphylococcus aureus, escherichia coli, klebsiella pneumoniae shows antagonistic and irrelevant relationship .

关 键 词：喜炎平注射液 抗菌药物 联合用药 体外抗菌活性 

分 类 号：R286[医药卫生—中药学]