中西医结合综合疗法治疗下肢动脉硬化闭塞症临床观察  

Clinical Observation on Combination of Traditional Chinese and Western Medicine in Treatment of Lower Limb Arteriosclerosis Obliterans

作　　者：王萌[1] 洪阳春[2] 李珍 WANG Meng HONG Yangchun LI Zhen(Guangzhou Panyu Hospital of Chinese Medicine,Guangzhou 511400,China Foshan Shunde Guizhou Hospital, Foshan 528305 ,China)

机构地区：[1]广州市番禺区中医院,广东广州511400 [2]佛山市顺德区桂洲医院,广东佛山528305

出　　处：《山东中医药大学学报》2017年第3期226-231,共6页Journal of Shandong University of Traditional Chinese Medicine

摘　　要：目的:观察桃红四物汤加减方内服联合中医外治疗法治疗动脉硬化闭塞症的临床效果。方法:将210例临床为动脉硬化闭塞症、辨证为瘀阻脉络型患者随机分为A组、B组和C组。三组在控制血压、血糖、血脂等基础治疗上,分别加用西药常规治疗(A组)、桃红四物汤加减方内服结合西药常规治疗(B组)及中西医结合综合治疗(C组)。检测血清凝血酶原时间(PT)、纤维蛋白原(FIB)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)水平,测量并计算各组患者治疗前及治疗后踝肱指数(ABI),通过B超测量各组患者治疗前及治疗后股浅动脉、胫后动脉和足背动脉的血管内径、峰值流速和血流量。结果:疗效显著性C组>B组>A组(P<0.05);血脂生化指标除PT及FIB治疗前后无统计学意义(P>0.05)外,其余指标均有所改善,且改善效果C组优于B组,更优于A组(P<0.01);三组治疗后ABI均有改善(P<0.05),且改善效果C组优于B组,更优于A组(P<0.01);三组治疗后B超检测项目均有改善(P<0.05),其中股浅动脉的血流量、足背动脉的峰值速度和血流量的改善效果C组及B组均明显优于A组(P<0.01),但C组优于B组不明显,其余检查指标三组内每两组间的治疗效果差异均有统计学意义(P<0.01),改善效果C组优于B组,更优于A组。结论:桃红四物汤加减方内服联合中医外治疗法治疗脉络瘀阻型下肢动脉硬化闭塞症可明显改善患者多项血脂生化及血流物理指标,疗效明显优于单纯西医及中药内服结合西药常规治疗。Objective：To observe the therapeutic effects of Taohong Siwu decoction combined with external therapy of traditional Chinese medicine on arteriosclerosis obliterans. Methods：Total 210 patients with arte- riosclerosis obliterans and blood stasis stagnating vessels syndrome were randomly divided into group A, group B and group C. Besides the basic treatment on blood pressure,blood fat and blood sugar,group A received routine western medicine treatment,group B were treated with Taohong Siwu decoction and western medicine,group C used the combination therapy of traditional Chinese and western medicine. PT,FIB,TG, TC,LDL-C and ABI before and after treatment were compared in the three groups. The vascular diameter, peak flowrate and blood flow volume of superficial femoral artery, dorsalis pedis artery and the posterior tib- ial artery were compared in the three groups. Results：The curative effect of group C was better than that in group B and group A（P〈0.05）. There were no statistical significance in PT and FIB in the three groups （P〉0.05）,but other biochemistry indexes were better and the improvement in group C was more significant than that in group B and group A after treatment（P〈0.01）. ABI in the three groups were all improved af- ter treatment（P〈0.05） and the improvement in group C was more significant than that in group B and group A（P〈0.01）. The results of ultrasonography in the three groups were all improved after treatment（P〈0.05）. The blood flow volume of superficial femoral artery and the peak flowrate and the blood flow volumeof dor-salis pedis artery were better improved in group B and group C than those in group A （P〈0.01）, while the difference between group C and group B was not significant. The other tests in ultrasonography had statistical significance between every two groups and the improvement in group C was more signifi- cant than that in group B and surely group A（P〈0.01）. Conclusion：Taohong Siwu decoction combined with external therapy of T

关 键 词：下肢动脉硬化闭塞症 瘀阻脉络型 桃红四物汤 中医外治疗法 

分 类 号：R269.544[医药卫生—中西医结合]