新型毒品N-甲基-N-异丙基-5-甲氧基色胺片剂的GC/MS检验方法研究  

Identification of Tablet-formulized N-methyl-N-isopropyl-5-methoxytryptamine with GC/MS

作　　者：赵彦彪[1] 郑晓雨[1] 郑珲[1] 高利生[1] 尹宝华[1] 刘占芳[1] 

机构地区：[1]公安部物证鉴定中心,北京100038

出　　处：《刑事技术》2017年第3期203-205,共3页Forensic Science and Technology

基　　金：中央级公益性科研院所基本科研业务费专项资金项目(No.2016JB007)

摘　　要：目的首次报道中国大陆出现的N-甲基-N-异丙基-5-甲氧基色胺片剂(5-MeO-MiPT),建立其气相色谱-质谱(GC/MS)定性分析方法,并阐述其在EI离子源轰击下的分子裂解机理。方法未知片剂样品研磨均匀后用甲醇提取,吸取上清液采用气相色谱-质谱(GC/MS)检测。结果测得未知组分(Rt=13.581min)的质谱特征碎片峰(m/z)信息为86.1(基峰)、246.1、159.9、117.0、44.0、145.0和130.0。经与标准物质的保留时间和质谱图比对,确定为N-甲基-N-异丙基-5-甲氧基色胺;通过查阅相关资料,对上述质谱特征碎片峰的产生机理进行了推断。结论该方法简单可靠,可用于N-甲基-N-异丙基-5-甲氧基色胺的检验。Objective To develop a GC/MS method for identification of N-metliyl-N-isopropyl-5-methoxytryptamine （5-MeO-MiPT） tablets said to emerge in China for the first time, together with a description on the mechanism of fragmentation from the molecule upon electron impacting （EI）. Methods The 5-MeO-MiPT-suspectful tablet was fully grinded and extracted with methanol, being subjected to centrifligation to obtain the supernatant that was in succession analyzed with GC/MS. Results One unknown component （Rt=13.581 min） was detected, appearing its characteristic fragment ion peaks at m/z 86.1 （base peak）, 246.1, 159.9, 117.0, 44.0, 145.0 and 130.0. Matched well to the standard reference substance of 5-MeO-MiPT with both the retention time and characteristic fragment ion peaks, the drug in the tested tablet was identified as N-methyl-N-isopropyl-5-methoxytryptamine. Furthermore, according to relevant literatures, the proposed pathway of EI- induced fragmentation of 5-MeO-MiP was described in detail. Conclusion A robust and reliable method was developed for 5-MeO-MiPT to be identified with GC/MS, capable of being applied into relevant cases.

关 键 词：5-MeO-MiPT GC/MS 裂解机理 

分 类 号：DF795.1[医药卫生—法医学]