动脉血栓相关治疗靶点及新药研究进展  

Advances in the research of therapeutic targets and the development of new drugs against arterial thrombosis

作　　者：李龙[1,2] 寇俊萍[1,2] 

机构地区：[1]中国药科大学江苏省中药评价与转化重点实验室,南京211198 [2]中国药科大学中药复方研究室,南京211198

出　　处：《中国药科大学学报》2017年第3期251-258,共8页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81274131)~~

摘　　要：动脉血栓(arterial thrombosis,AT)为一种临床常见病及多发病,并可诱发急性心肌梗死、缺血性脑卒中等缺血性心脑血管疾病,具有高致残率和高致死率的特点,严重危害人类健康。AT形成过程中涉及到内皮细胞、白细胞、血小板等多种因素的参与。积极寻找AT形成过程中可干预进程的治疗靶点,并根据靶点开发相关治疗药物具有重大的意义。本文就近5年来防治AT形成和抗栓治疗涉及到的相关靶点研究现状,及针对上述靶点研发的抗栓药物进展研究作一综述,以期为研制治疗AT的创新药物提供可能线索和依据。Arterial thrombosis（AT）is a common disease which usually causes acute myocardial infarction, ischemic stroke and other ischemic cardiovascular and cerebrovascular diseases, which shows high rates of morbidity and mortality, and has become a serious problem to human health. It is increasingly clear that the interactions among platelets, the endothelium and leukocytes are important throughout all stages of the atherothrombotic process. It is of great significance to search for therapeutic targets in the process of AT and developing the therapeutic drugs based on those newly discovered targets. This article reviews the research advances in the discovery of antithrombotic targets and the current situation of drug development based on those antithrombotic targets found in the recent 5 years, in order to provide some references or clues for the development of innovative drugs to prevent and treat AT.

关 键 词：动脉血栓 动脉粥样硬化 治疗靶点 受体 新药研发 

分 类 号：R972[医药卫生—药品]