鸡与鸭重要免疫相关基因结构与功能差异及其禽流感抗性关联分析  

Structural and functional differences of major immune-related genes between duck and chicken and their association with resistance against influenza virus

作　　者：李国勤[1] 陈黎[1] 田勇[1] 卢立志[1] 

机构地区：[1]浙江省农业科学院畜牧兽医研究所,杭州浙江310021

出　　处：《中国兽医学报》2017年第6期1186-1192,1200,共8页Chinese Journal of Veterinary Science

基　　金：国家现代农业产业技术体系资助项目(CARS-43-2);浙江省公益技术研究农业资助项目(2014C32063)

摘　　要：禽流感(AI)是禽流感病毒(AIV)引起的一种急性传染病。天然免疫是宿主抵抗病毒感染的第一道防线,在机体抗病毒感染过程中发挥重要作用。鸭和鸡是H5N1AIV感染和传播的主要宿主,但鸭对AI禽流感的抗性远大于鸡,目前公认与其机体天然免疫相关基因有关。比较这两种亲缘关系相近模式生物的遗传结构,可以揭示AI抗性差异的分子基础。本文比较分析鸭和鸡主要免疫相关基因的结构与功能及其在AIV抗性差异方面的潜在作用,为AI防控新技术研究提供理论基础。Avian influenza（AI） is a highly contagious viral disease in birds. The innate immune sys- tem serves as a first line of defence against invading pathogens including avian influenza viruses. Duck and chicken are the most important hosts in the maintenance and transmission cycles of in- fluenza A viruses,but ducks are more resistant to avian influenza than chickens, which is thought to be related to innate immune response genes. A comparison of the genetic makeup between these two closest genetic model organisms could provide important insights into the molecular basis for this susceptibility difference. The review summarizes the structural and functional difference of major immune-related genes between duck and chicken as well as their implications on differential avian resistance against influenza virus.

关 键 词：家禽 免疫相关基因 同源性 禽流感 抗性 

分 类 号：S852.4[农业科学—基础兽医学]