电荷反转型纳米给药系统的分类及在肿瘤治疗中的应用  

Charge-Reversal Nano Drug Delivery System:Classification and Application in Cancer Therapy

作　　者：郭爱洁[1] 薛继杨[1] 张骁[2] 

机构地区：[1]同济大学附属第一妇婴保健院药剂科,上海201204 [2]浙江大学医学院附属妇产科医院药剂科,杭州310006

出　　处：《中国药学杂志》2017年第11期910-917,共8页Chinese Pharmaceutical Journal

摘　　要：针对肿瘤特殊结构及理化性质而设计的刺激响应型纳米给药系统越来越引起研究者们的关注,电荷反转型纳米给药系统(charge-reversal nano drug delivery system,CRN-DDS)就是其中之一。CRN-DDS可以有效地结合正、负电荷在药物体内递送过程中的优势,且有很好的肿瘤靶向性。虽然CRN-DDS应用于肿瘤治疗的研究已有文献报道,但相关的中文文献,尤其是综述型文献很少。为此,笔者查阅了近6年来CRN-DDS的相关文献资料,按照电荷反转的不同机制对CRN-DDS进行了归纳分类,分析和总结了其在肿瘤治疗中的应用研究,对CRN-DDS的发展和应用前景进行了初步展望。Stimuli-responsive nano drug delivery systems based on specific structures and physicochemical properties of tumor have been drawing wide attention from researchers, one of which is charge-reversal nano drug delivery system（CRN-DDS）. CRN-DDS can effectively combine the merits of positive and negative charges in the drug delivery process in vivo, and it also has the good property of tumor-targeting. Although studies of CRN-DDS application in cancer therapy have already been reported, there is very little relevant Chinese literature, especially review articles. To fill in the blank, the foreign literatures about CRN-DDS were looked up in the last six years, classified CRN-DDSs by their different approaches of surface charge reversal, and summarized the studies on their applications in the cancer therapy. Last but not least, the prospect of CRN-DDS＇s development and application was preliminarily looked into in this article.

关 键 词：刺激响应 表面电荷 电荷反转 纳米给药系统 肿瘤治疗 

分 类 号：R944[医药卫生—药剂学]