神经营养素3及其受体在大鼠耳蜗螺旋神经节发育中的作用研究进展  

Progress in the role of neurotrophin-3 and its receptors in the development of cochlear spiral ganglion in rats

作　　者：郭春飞[1] 金永德[1] 金玉莲[1] 

机构地区：[1]延边大学附属医院(延边医院)耳鼻咽喉头颈外科,吉林延吉133000

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第12期968-971,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金资助项目(No:81160127)

摘　　要：神经营养素3（neurotrophin-3,NT-3）作为神经营养素家族的重要一员被广泛应用在神经细胞损伤修复研究方面。无论是在周围神经还是中枢神经损伤修复上NT-3都扮演着重要角色。由于NT-3直接应用于临床是否安全缺乏有效的循证医学证据,目前NT-3仍处于动物实验阶段未被应用于临床。通过基因转染技术使神经干细胞表达NT-3促进神经修复被证实有效[1]。Neurotrophin-3（NT-3 ）attracted increasing attention about NTFs researches in recent years. But the mechanism of promoting the development of neurons and neurite extension is not clear. Recombinant human NT-3 or NT-3 gene is commonly used in the treatment of peripheral and central neurons system damage. When rats are born, the cochlear is not mature yet. It is a suitable experimental animal for studying the morphological and functional development of the peripheral auditory pathway. It was found that NT-3 could promote the surviv- al, growth, division and extension of the cochlear neurons in rats. To make clear the role of NT 3 in the develop- ment of spiral ganglion in the rat cochlear will be of significance for the treatment of nervous hearing loss by NT- 3 in the future.

关 键 词：神经营养素3 大鼠 耳蜗 螺旋神经节 

分 类 号：R764[医药卫生—耳鼻咽喉科]