基于粉体学性质分析浸膏干燥工艺与中药配方颗粒制粒质量的相关性  

Analysis on relativity of drying process of extract and pelleting quality of Chinese materia medica formula granule based on powder properties

作　　者：李远辉[1] 伍振峰[2] 李延年[1] 李慧婷[1] 杨明[1,2] 

机构地区：[1]成都中医药大学药学院,四川成都610072 [2]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《中草药》2017年第10期1930-1935,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81673613);江西省科技条件平台建设项目(20142BCD40037)

摘　　要：中药配方颗粒以中药浸膏粉为中间体加适宜的辅料制成,中药浸膏粉的粉体学性质如粒径、吸湿性、流动性等直接影响中药配方颗粒的制粒质量。而干燥是制备中药浸膏不可或缺的操作单元之一,对浸膏的粉体学性质有较大影响。因此,中药浸膏的干燥工艺与中药配方颗粒的制粒质量存在一定相关性。通过文献调研,归纳了各主要制粒方法的工程原理与特点,分析了制粒质量评价要素,并结合实验研究,以粉体学性质为视角探讨了浸膏干燥工艺与中药配方颗粒制粒质量的相关性,并提出应重视中药浸膏的干燥工艺研究,以期进一步提高中药配方颗粒的制粒质量。Chinese materia medica （CMM） formula granule is made from CMM extract powder and suitable pharmaceutical excipients, pOwder properties of CMM extract powder such as the particle size, hydroscopicity, and fluidity directly affect thepelleting quality of CMM formula granule. Drying is one of the indispensable operating units for preparations of CMM extract, which has great influence on the powder properties of CMM extract powder. Therefore, there is a certain correlation between the drying process and pelleting quality of CMM formula granule. Through the literature research, this paper summarizes the engineering principle and characteristics of each main granulation method, analysis of the evaluation factors of pellet quality, and combines with experimental research to explore the correlation between the drying process of CMM extract and pelleting quality of CMM formula granule in the perspective of powder properties. Finally, we puts forward that more attention should be payed to study the drying process of CMM extract, in order to further improve the quality of pelleting quality of CMM formula granule.

关 键 词：粉体学性质 中药浸膏 干燥工艺 中药配方颗粒 制粒质量 

分 类 号：R283.3[医药卫生—中药学]