碱偏离型恩诺沙星注射液的临床应用研究  

The Clinical Application Study on Alkali Deviation Type Enrofloxacin Injection

作　　者：刘鼎阔[1,2,3] 刘树明[4] 王立红[2,3] 赵晶晶[2,3] 张俊霞[3] 刘芳[2,3] 

机构地区：[1]中国农业大学动物医学院,北京100094 [2]天津市饲用微生物制剂企业重点实验室,天津300383 [3]鼎正动物药业(天津)有限公司,天津300383 [4]吉林农业大学动物科学技术学院,长春130118

出　　处：《中国兽药杂志》2017年第6期49-55,共7页Chinese Journal of Veterinary Drug

基　　金：国家农业科技成果转化资金项目(2013GB2A100020)

摘　　要：为研究碱偏离型恩诺沙星注射液对人工感染大肠杆菌O_(78)雏鸡的治疗作用,本试验以8日龄的雏鸡为试验动物,腹腔注射一定剂量的O_(78)菌悬液,建立雏鸡大肠杆菌人工感染模型,然后给予不同剂量碱偏离型恩诺沙星注射液对其进行治疗试验。结果显示,给予1.75 mg/kg碱偏离型恩诺沙星注射液进行预防给药,其增重率显著升高,增重率和有效率分别为102.45%和100%;给予1.75 mg/kg碱偏离型恩诺沙星注射液进行治疗给药,雏鸡增重率、治愈率和有效率分别为93.34%、70%和83%,试验证明,碱偏离型恩诺沙星注射液能有效防治人工感染雏鸡大肠杆菌病。To study the therapeutic effect of alkali deviation type enrofloxacin in chicken which were infected artificially with the O78 E. coli （Escherichia coli ）, 8-day-old chicken were choosed to take intraperitoneal injection of a certain dose of O7s E.coli bacterial suspension to establish E.coli infection model. And then chicken were treated with various doses of alkali deviation type enrofl-oxacin injection. The result showed that the weight gain rate improved significantly with alkali deviation type enrofloxacin injection （1.75 mg/kg） treated for prevention. The weight gain rate and the effective rate was respectively 102.45% and 100% . While the weight gain rate, the effective rate and the cure rate was respectively 58.34%, 70% and 83% with alkali deviation type enrofloxacin injection （ 1.75 mg/kg） treated for therapy. The experiment showed that the alkali deviation type enrofloxacin injection has obvious therapeutical effect on colibacillosis infected artificially with OTs E. coli, which provided theoretical support in clinical usage.

关 键 词：碱偏离型恩诺沙星注射液 大肠杆菌病 预防和治疗试验 

分 类 号：S859.796[农业科学—临床兽医学]