2-巯基-5-硝基苯并咪唑的连续化合成研究  

Study on Continuous Synthesis of 2-mercapto-5-nitrobenzimidazole

作　　者：陈晓禹[1] 胡博淳 丁振中 张超 王文龙[1] 

机构地区：[1]江南大学药学院,江苏无锡214122 [2]扬州日兴生物科技股份有限公司,江苏扬州225601

出　　处：《广州化工》2017年第11期43-44,共2页GuangZhou Chemical Industry

基　　金：江苏省政策引导类计划(No:BY2016022-37)

摘　　要：艾普拉唑是新一代的质子泵抑制剂,主要用于治疗十二指肠等消化性溃疡为主的肠胃疾病,具有抑酸效果强,作用持久等优势。已在27个国家申请了专利,并于2007年成功上市,2016年销售额达到1.2亿元。本文提供一种以4-硝基邻苯二胺为原料制备艾普拉唑关键中间体2-巯基-5-硝基苯并咪唑的连续化合成方法。本方法具有操作简便、安全环保、产率高等特点。Epoprazole is a new generation of proton pump inhibitors, and mainly treats duodenal ulcer ano omer peptic ulcer-based gastrointestinal diseases. It has patent application in 27 countries, successfully reached annual sale of 120 million yuan in 2016. Flow chemistry was used to synthesize 2-mereapto-5-nitrobenzimidazole, which was the key intermediate of epoprazole, and a potent enviromently friendly way to make epoprazole was offered.

关 键 词：艾普拉唑 苯并咪唑 连续化反应技术 安全环保 

分 类 号：TQ463.4[化学工程—制药化工]