肺心病呼吸衰竭患者凝血功能及心电图变化特点及临床治疗效果的分析  

Changes of Blood Coagulation Function and Electrocardiogram in Patients with Pulmonary Heart Disease Complicated with Respiratory Failure and the Effect of Clinical Treatment

作　　者：曹薇[1] 范荣梅[2] 

机构地区：[1]湖北医药学院附属人民医院医务科,十堰442000 [2]湖北医药学院附属人民医院呼吸内科,十堰442000

出　　处：《血栓与止血学》2017年第4期564-567,共4页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的分析肺心病呼吸衰竭患者凝血功能及心电图变化特点,并探讨其临床治疗效果。方法抽取肺心病并呼吸衰竭患者78例与健康体检人群50例,分别计为观察组与正常对照组,检测比较两组心电图、凝血功能指标检测,另外观察组患者均接受无创通气、丹参多酚酸盐等综合治疗,观察临床治疗效果。结果观察组心律失常(激动起源异常、激动传导异常、酷似心梗)发生率显著高于正常对照组(P<0.05);观察组治疗前PT、a PTT、TT、PaO_2、SaO_2显著低于正常对照组,Fbg、全血高切黏度、全血低切黏度、血浆黏度、PaCO_2显著高于正常对照组(P<0.05);与治疗前比较,观察组治疗后PT、a PTT、TT、PaO_2、SaO_2显著上升,Fbg、全血高切黏度、全血低切黏度、血浆黏度、PaCO_2显著下降(P<0.05)。结论肺心病呼吸衰竭患者易发生心律失常,处于血液高凝状态;无创通气+丹参多酚酸盐能明显改善患者血液高凝状态及血液流变学指标,提高临床治疗效果。Objective To analyze the changes of coagulation function and electrocardiogram in patients with pulmonary heart disease complicated with respiratory failure, and explore the clinical therapeutic effect. Methods Seventy-eight patients with pulmonary heart disease complicated with respiratory failure （observation group ）and 50 healthy people （normal control group ）were enrolled in the study. The electrocardiogram and coagulation function indexes were detected and compared. The observation group was additionally treated with noninvasive ventilation and salvianolate, and the clinical efficacy was observed. Results The incidence rate of arrhythmia （abnormal activation, abnormal conduction, mimicking myocardial infarction） in the observation group was significantly higher than that in control group （ P 〈 0. 05 ） ; Before treatment, FT, aFFF, TT, PaO2 and SaO2 in observation group were significantly lower than those in normal control group, while Fbg, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and PaCO2 were significantly higher（ P 〈 0.05 ） ; After treatment, PT, aFVF, 3T, PaO2 and SaO2 in observation group increased significantly while Fbg, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and PaCO2 decreased significantly （P 〈 0.05） , and the above indexes in group B were significantly better than those in group A （ P 〈 0. 05 ）. Conclusion Patients with puhnonary heart disease complicated with respiratory failure are prone to have arrhythmias and in hypercoagulable state;Noninvasive ventilation combined with salvianolate can significantly relieve hypercoagulable state and hemorheology, and improve the clinical effect.

关 键 词：肺心病 呼吸衰竭 凝血功能 心电图 

分 类 号：R1[医药卫生—公共卫生与预防医学]