急性心肌梗死介入治疗中血栓抽吸联合替罗非班的疗效分析  

Analysis of the Efficacy of Thrombus Aspiration Combined with Non shift in the Treatment of Acute Myocardial Infarction

作　　者：黄宇辉[1] 许春平[1] 曾波[1] 

机构地区：[1]南宁市第一人民医院心血管内科,南宁530022

出　　处：《血栓与止血学》2017年第4期577-579,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨急性心肌梗死(AMI)介入治疗(PCI)中血栓抽吸联合替罗非班的临床疗效及安全性。方法通过对我院2012年6月至2015年7月100例AMI行急诊PCI患者病例资料做回顾性分析,并根据治疗方法的不同,将其分为对照组,观察组(各50例),记录并比较两组患者的术后血流情况、心功能参数、预后情况。结果两组患者经相应方案治疗后观察组的IRA的TIMI3级血流、ST段50%回落百分比、术后2个月LVEF均明显高于对照组,差异具有统计学意义(P<0.05),观察组CKMB峰值及峰值时间、IRA慢复流或无复流、MACE发生率、术后2个月LVDd均明显优于对照组,差异具有统计学意义(P<0.05),且术后第7 d LVEF及LVDd、术后出血情况比较无统计学意义(P>0.05)。结论在AMI介入治疗中应用血栓抽吸联合替罗非班可降低无复流或慢血流的发生率,有效的改善心肌灌注及预后。Objective To investigate the clinical efficacy and safety of thrombus aspiration combined with non shift in the treatment of acute myocardial infarction. Methods Analyzed the data of 100 cases of patients with emergency PCI retrospectively in our hospital from June 2012 to July 2015. According to the different treatment methods, divided them into the control group and the observation group （50 cases ）. Recorded and compared the blood flow, cardiac function parameters and prognosis of the two groups. Results After treatment, TIMI3 grade IRA blood flow, ST segment 50% percentage, the LVEF level 2 months after treatment of the observation group were significantly higher than the control group, and the difference was statistically significant（P 〈 0.05 ）. The CKMB peak value and peak time, IRA slow reflow or no reflow, the incidence of MACE, LVDd Level 2 months after operation of the observation group were significantly better than the control group, the difference was statistically significant （P 〈 0. 05 ）. And seventh days after operation, there were not statistically significant in the levels of LVEF and LVDd between the two groups （ P 〉 0. 05）. Conclusion The incidence of no reflow or slow flow can be reduced by using thrombus aspiration combined with non-class in the treatment of AMI, which can effectively improve the myocardial perfusion and prognosis.

关 键 词：急性心肌梗死 介入治疗 血栓抽吸 替罗非班 

分 类 号：R542.2[医药卫生—心血管疾病]