小剂量左甲状腺素治疗良性甲状腺结节疗效观察  

To observe the efficacy of low-dose left thyroxine in the treatment of benign thyroid nodules

作　　者：龚玉萍[1] 张雅薇[1] 赖轻舟 GONG Yuping ZHANG Yawei LAI Qing zhou(Pingxiang City People＇s Hospital, Pingxiang 337000, Chin)

机构地区：[1]萍乡市人民医院,江西萍乡337000

出　　处：《临床医药实践》2017年第6期431-433,共3页Proceeding of Clinical Medicine

摘　　要：目的:观察小剂量左甲状腺素治疗良性甲状腺结节的疗效。方法:选取116例良性甲状腺结节患者,根据就诊时间的先后顺序分为观察组和对照组,每组各58例。观察组给予小剂量左甲状腺素治疗,对照组给予适量安慰剂治疗,7 d为1疗程,连续5个疗程。比较两组的促甲状腺激素和游离甲状腺激素水平、甲状腺结节大小变化情况及随访期不良反应发生情况。结果:两组治疗前促甲状腺激素和游离甲状腺激素水平及结节大小比较差异均无统计学意义(P>0.05),两组治疗后激素水平及结节大小均有一定程度的改善,且观察组促甲状腺激素水平明显低于对照组(P<0.05),游离甲状腺激素水平明显高于对照组(P<0.05),结节大小明显小于对照组(P<0.05);观察组不良反应发生率3.45%,对照组10.34%,差异无统计学意义(P>0.05)。结论:小剂量左甲状腺激素治疗良性甲状腺结节疗效显著,改善机体促甲状腺激素和游离甲状腺激素水平,高效且安全。Objective ： To observe the therapeutic effect of low - dose left thyroxine in benign thyroid nodules. Methods ： All 116 patients with benign thyroid nodules were selected and divided into observation group and control group according to the order of treatment time. The control group received low- dose left thyroxine treatment, the control group given appropriate pla- cebo treatment,7 d for a course of treatment for 5 consecutive courses. The levels of thyrotropin and free thyroid hormone, the change of thyroid nodule size and the occurrence of adverse reactions during follow - up were compared between the two groups. Results：There was no significant difference in the levels of thyrotropin and free thyroid hormone and nodule size be- tween the two groups （ P 〉 0.05 ）. After treatment, the levels of hormone and nodule were improved to some extent, and the lev- el of thyrotropin in the observation group was significantly lower than that in the control group （ P 〈 0.05 ）. The level of free thyroid hormone was significantly higher than that of the control group （P 〈 0.05 ）. The nodule size was significantly lower than that of the control group （ P 〈 0.05 ）. The incidence of adverse reactions in the observation group was 3.45 %, which was slightly higher than that of the control group （ 10.34% ）, the difference was not statistically significant （ P 〉 0.05 ）. Conclusion ： Benign thyroid nodules small dose of left thyroid hormone treatment is significant, improve the body to promote thyroid hormone and free thyroid hormone levels, efficient and safe.

关 键 词：甲状腺结节 小剂量 左甲状腺素 疗效 

分 类 号：R581.33[医药卫生—内分泌]