狼疮性膀胱炎的临床特征及危险因素分析  

Clinical feature and risk factor of lupus cystitis

作　　者：戴晓丹[1] 肖亦之[1] 蒋莹[1] 谢晓韵[1] 黄婧[1] 谢艳莉[1] 宁旺斌[1] 赵洪军[1] 罗卉[1] 游运辉[1] 左晓霞[1] 周亚欧[1] 

机构地区：[1]中南大学湘雅医院风湿免疫科,湖南长沙410008

出　　处：《中国现代医学杂志》2017年第11期63-67,共5页China Journal of Modern Medicine

基　　金：2015年度"湘雅医院-北大未名临床与康复研究基金"(No:xywm2015118)

摘　　要：目的分析狼疮性膀胱炎患者的临床特征及危险因素。方法选取27例确诊的狼疮性膀胱炎的住院患者作为病例组,并选取性别、年龄及病程相匹配的无狼疮性膀胱炎的系统性红斑狼疮(SLE)住院患者共135例作为对照组,回顾性分析两组间临床表现、实验室检查与影像学的差异;通过Logistic回归分析初步探讨狼疮性膀胱炎的危险因素。结果狼疮性膀胱炎的发生率1.3%,主要表现为下尿路症状、双侧输尿管扩张及肾积水等;与对照组相比,狼疮性膀胱炎患者的胃肠道症状的发生率高于无狼疮性膀胱炎的患者,但狼疮性肾炎和蛋白尿的发生率低于后者,差异有统计学意义(P<0.05);SLE合并狼疮性膀胱炎组患者补体低于对照组,抗SSA抗体的阳性率高于对照组(P<0.05);狼疮性膀胱炎组SLEDAI评分低于对照组(P<0.05);Logistic回归分析发现胃肠道症状、低补体为狼疮性膀胱炎的危险因素。结论胃肠道症状及低补体为狼疮性膀胱炎的危险因素,抗SSA抗体与狼疮性膀胱炎密切相关。Objective To explore the clinical features and risk factors of lupus cystitis. Methods A total of 162 patients with systemic lupus erythematosus （SLE） were enrolled, among whom 27 patients with lupus cystitis. The clinical manifestations, laboratory findings and radiographic differences between the two groups were analyzed retrospectively. The clinical characteristics and the risk factors of patients with lupus cystitis were analyzed. Results The incidence of lupus cystitis was 1.3%. The main clinical manifestations were lower urinary tract symptoms, hydronephrosis and bilateral ureteral dilatation. The incidences of gastrointestinal symptoms in lupus cystitis patients were significantly higher than those in SLE patients without lupus cystitis （P 〈 0.05）, while the incidence of lupus nephritis and proteinuria were statistically lower than those in the control group （P 〈 0.05）. The positive rate of anti-SSA antibody and the SLEDAI score in patients with lupus cystitis were lower than that in control group （P〈 0.05）. Logistic regression analysis showed that gastrointestinal symptoms and low complement were the risk factors of lupus cystitis. Conclusions Gastrointestinal symptoms and low complement are risk factors of lupus cystitis. Anti-SSA antibody is closely related to lupus cystitis.

关 键 词：狼疮性膀胱炎 危险因素 临床特征 输尿管扩张 肾积水 胃肠道症状 抗SSA抗体 

分 类 号：R593.24[医药卫生—内科学]