健脾补肾解毒法方药对猴艾滋病的免疫调节作用  

Immune regulation effect of Chinese medicine of invigorating spleen and kidney detoxification on simian immunodeficiency virus-infected rhesus macaque

作　　者：张苗苗[1,2] 符卓韬[3] 陈剑涛[2] 成业[2] 朱伯强 符林春[2] 周红燕[2] 

机构地区：[1]河北大学中医系,河北保定071000 [2]广州中医药大学热带医学研究所,广东广州510407 [3]广州中医药大学第一附属医院,广东广州510405

出　　处：《中国中药杂志》2017年第11期2152-2158,共7页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81302897;81173436);国家"重大新药创制"科技重大专项(2014ZⅩ10005002);河北大学中西部提升综合实力专项资金

摘　　要：为了评价健脾补肾解毒法中药对猴艾滋病的干预效果。该实验选用8只同期SIV感染恒河猴,随机分为2组:健脾补肾解毒法中药组(以下简称中药组)和抗病毒药组,分别给予中药及抗病毒治疗8周,每4周采集外周血检测。结果显示,健脾补肾解毒法中药虽然不能像HAART一样明显降低血浆病毒载量,但可以升高外周血CD4,该亚群主要为CD4纯真细胞;使CD4和CD8功能细胞数量增加,增强对病原体的免疫应答;在一定程度上延缓了脾虚的出现和进展。表明该药有较好的免疫调节作用,具有相当的临床价值和应用前景。To evaluate the effect of Chinese medicine of invigorating spleen and kidney detoxification on simian immunodeficiency virus-infected rhesus macaque. Eight SIV rhesus macaques of the same age were randomly divided into Chinese medicine of invigorating spleen and kidney detoxification group（ hereinafter referred to as Chinese medicine group） and anti-virus drug（HAART） group. The traditional Chinese medicine and antiviral therapy were given for 8 weeks, and peripheral blood was collected for detection in every 4 weeks. The results showed that Chinese medicine of invigorating spleen and kidney detoxification could not obviously decrease plasma viral load as HAART, but it can increase CD4 number in peripheral blood, especially the CD4 naive cells, and increase the number of CD4 and CD8 cells, enhance the immune response to pathogens. Therefore, it delayed the occurrence and development of spleen deficiency to a certain extent, indicating that the medicine had immune regulation effect, with considerable clinical value and application prospects.

关 键 词：艾滋病 中药 免疫调节 

分 类 号：R285.5[医药卫生—中药学]