原发性干燥综合征患者血清TPO及HPA的表达及临床意义  

TPO and HPA expression level and clinic significance of patients with PSS

作　　者：庞琳烜 谢荣华[1] 吴振彪[1] 杨西超[1] 郑朝晖[1] 

机构地区：[1]第四军医大学西京医院临床免疫科,陕西西安710032

出　　处：《西部医学》2017年第6期830-834,838,共6页Medical Journal of West China

基　　金：陕西省自然科学基金项目(2014JM2-8121)

摘　　要：目的研究原发性干燥综合征患者血清促血小板生成素(TPO)和人类血小板抗原(HPA)的表达水平及临床意义,旨在为临床治疗提供相关理论依据。方法选取我院临床免疫科2014年2月至2016年2月收治的原发性干燥综合征患者60例作为观察组,另选取来我院做健康体检者60例作为对照组,观察被检者促血清血小板生成素(TPO)与人类血小板抗原(HPA)的表达水平,同时检测其他相关临床指标表达水平。结果血小板减少组、曾有血小板减少组及血小板正常组患者一般资料比较无差异(P>0.05);观察组血清TPO表达水平明显高于对照组(P<0.05),观察组血清HPA表达水平与对照组比较无差异(P>0.05);观察组根据有无血小板减少症再分为血小板减少组、曾有血小板减少组及血小板正常组血清TPO表达水平明显高于对照组(P<0.05),血小板减少组、曾有血小板减少组及血小板正常组三组患者组内比较无差异(P>0.05);血小板减少组、曾有血小板减少组、血小板正常组血清HPA表达水平与正常比较无差异(P>0.05),4组间两两比较无差异(P>0.05);血小板正常组患者lgA、CIC表达水平明显高于血小板减少组及曾有血小板减少组(P<0.05),血小板减少组、曾有血小板减少组及血小板正常组患者WBC、RBC、ESR、CRP、lgG、lgM、C3、C4、SSA-Ab、SSB-Ab、HB、lgE各临床指标间比较无差异(P>0.05);lgA、CIC两指标组间多重比较:血小板减少组CIC表达水平与曾有血小板减少组及血小板正常组比较无差异(P>0.05),曾有血小板减少组CIC表达水平与血小板正常组比较有差异(P<0.05);血小板减少组lgA表达水平与曾有血小板减少组比较无差异(P>0.05),血小板正常组lgA表达水平与血小板减少组及曾有血小板减少组比较均有差异(P<0.05),血清TPO表达水平与各临床指标间均无相关性(P>0.05),血清HPA表达水平与临床指标间无相关性(P>0.05),HB与抗SSA-Ab抗体呈负相关(r=-0Objective To investigate PO and HPA expression level and clinic significance of patients with PSS in order to provide basis for clinic treatment. Methods 60 patients with PSS in our hospital from February 2014 to February 2016 were selected as observation group. 60 healthy people were chosen as control group. TPO and HPA expression level and other clinic indexes, including WBC, RBC, PLT, HB, ESR, CRP, ANA, anti SSA antibody, anti SSB antibody, G（IgG）, A（IgA）, M（IgM）, 3（C3）, 4（C4） and CIC were observed. Results Difference among thrombopenia group, used thrombopenia group and platelet normal group was not statisticly significant （P〉0.05）. TPO expression level of observation group was obviously higher than that of control group （P〈0.05）. HPA of the two groups had no statistic significance （P〉0.05）. TPO of thrombopenia group, used thrombopenia group and platelet normal group were obviously higher than that of control group （P〈 0.05）. HPA of thrombopenia group, used thrombopenia group and platelet normal group had no difference from that of control group （P〉0.05）. lgA and CIC of platelet normal group were higher than thrombopenia group and used thrombopenia group （P〈0.05）. WBC, RBC, ESR, CRP,lgG, lgM, C3, C4, SSA-Ab, SSB-Ab, HB and lgE of three groups had no statistic significance （P〉0.05）. The difference of CIC between thrombopenia group and used thrombopenia group had no statistic significance （P〉0.05）. The difference of CIC between thrombopenia group and platelet normal group had statistic significance （P〈 0.05）. The difference of lgA between thrombopenia group and used thrombopenia group had no statistic significance （P〉0.05）. The difference of lgA between platelet normal group, thrombopenia group and used thrombopenia group had statistic significance （P〈0.05）. TPO had no correlation with clinic indexes （P〉0.05）. HPA had no correlation with clinic indexes （P〉0.05）. HB and anti SSA- Ab were negatively correlated（r=-0

关 键 词：原发性干燥综合征 血小板生成素 人类血小板抗原 表达水平 

分 类 号：R593.2[医药卫生—内科学]