Plackett-Burman联合Box-Behnken设计法优选杏苏止咳颗粒流化床制粒工艺研究  

Optimization of the Fluidized Bed Granulation Process of Xingsuzhike Granules with Plackett-Burman and Box-Behnken Design

作　　者：谈华明 罗莉 徐瑞超 董自亮 

机构地区：[1]太极集团重庆涪陵制药厂有限公司,重庆408099

出　　处：《亚太传统医药》2017年第12期25-28,共4页Asia-Pacific Traditional Medicine

基　　金：国家科技重大专项课题(2013ZX09508-105)

摘　　要：目的:优化杏苏止咳颗粒流化床制粒的最佳工艺。方法:以杏苏止咳颗粒合格率为指标,采用Plackett-Burman设计筛选杏苏止咳颗粒流化床制粒的主要影响因素;再以颗粒的合格率和休止角为评价指标,采用Box-Behnken设计对影响流化床制粒工艺的主要因素进一步优化,对实验数据进行多元线性回归、二项式拟合,分析预测最佳工艺。结果:杏苏止咳颗粒流化床制粒的最佳工艺条件为:进风温度为75℃,进料速度为47r·min-1,浸膏相对密度为1.138(60℃),物料温度为60℃,风机频率为35Hz,雾化压力为0.4MPa。结论:采用Plackett-Burman设计和Box-Behnken设计法优化杏苏止咳颗粒流化床制粒工艺科学合理,优选的工艺稳定可靠,为杏苏止咳颗粒的工业化生产提供了可靠依据。Objective： To optimize the fluidized bed granulation process of Xingsuzhike granules. Methods：Take the qualified gran- ule rate as index, we screened the significantly influence factors of the fluidized bed granulation process of Xingsuzhike granules using Plackett Burman. On this basis, take the qualified rate and angle of repose of granules as index, and the significant factors that a/fect the process of fluidized bed were optimized by Box-Behnken design. The experimental data were analyzed by multiple linear regression and binomial fitting analysis to predict the optimum application of response surface method. Results： The optimum conditions of fluidized bed granulation of Xingsuzhike granules： inlet temperature of 75℃, feed speed 47 revolutions per minute, the relative den- sity of the extract 1. 138 （60℃）, the material temperature of 60℃, fan frequency of 35Hz, atomization pressure 0.4MPa. Conclusion：The Plackett Burman design and box Behnken design using response surface methodology for the optimization of fluidized bed granulation process prediction of Xingsuzhike granules is good, the optimal technology is stable and reliable, apricot Sue cough granule industrialization production provides a reliable basis.

关 键 词：杏苏止咳颗粒 PLACKETT-BURMAN设计 BOX-BEHNKEN设计 流化床制粒 

分 类 号：R283[医药卫生—中药学]