增加胸穿抽液次数联合尿激酶治疗结核性胸膜炎的疗效观察  

The Effect of Combined Urokinase Injection with Increased Number of Pleural Puncture Pumping Fluid in Treatment of Patients with Tuberculous Pleurisy

作　　者：宋刚[1] 贾文鹏[1] 

机构地区：[1]解放军第313医院呼吸内科,辽宁葫芦岛125000

出　　处：《中国医药指南》2017年第16期39-40,共2页Guide of China Medicine

摘　　要：目的探讨增加胸穿抽液次数联合尿激酶治疗结核性胸膜炎疗效观察效果。方法 80例中大量胸腔积液结核性胸膜炎患者随机均分两组:A组常规抗结核治疗,超声引导下2~3次/周胸穿抽液;B组常规抗结核治疗,超声引导下4~6次/周胸穿抽液;A组在超声示胸水深度<2 cm以下或出现多个细小分隔无法定位时,不再进行胸穿抽液,B组在每次抽液后超声检查若有分隔注入尿激酶10万U+生理盐水10 mL,6~24 h行胸穿抽液,至超声示胸水深度<2 cm以下,不再行胸穿抽液。结果 B组在胸水控制时间、胸膜增厚、积液包裹、住院天数均优于A组。结论增加胸穿抽液次数联合胸腔内注入尿激酶能有效减少胸膜增厚、积液包裹与A组有显著差异。Objective To study the clinical effect of combined urokinase injection with increased number of pleural puncture pumping fluid in treatment of patients with tuberculous pleurisy. Methods 80 cases patients with tuberculous pleurisy of massive-moderate pleural effusion were randomly divided into two groups： group A ultrasonic guided by 2-3 times per week pleural puncture fluid; group B ultrasound guided by 4 to 6 times per week pleural puncture fluid, both of them for anti-tuberculosis treatment. In group A when hydrothorax depth 〈2 cm below or multiple small space can＇t locate, stop to pleural puncture pumping liquid, group B ultrasound after each extraction liquid if there ,are separate injection of urokinase 10 million U ＋ saline 10 mL, pleural ! puncture pumping fluid again 6-24 hours later until hydrothorax depth 〈 2 cm below. Results The control time of hydrothorax, pleural thickening and effusion, hospitalization days in group B were better than that of group A. Conclusion To increase the.number of pleural puncture pumping fluid combined with urokinase injection can effectively reduce pleural thickening and effusion have significant difference with group A.

关 键 词：胸穿 尿激酶 结核 胸膜炎 

分 类 号：R521.7[医药卫生—内科学]