云艾散对大鼠胃溃疡愈合的影响  

Effect of Yun'ai Powder for Curing Gastric Ulcer of Rats

作　　者：张芷嫣 陈婉珍[1] 刘宇旻 王辉[1] 金兑殷 严展鹏[1] 朱方石 

机构地区：[1]南京中医药大学第三临床医学院,江苏南京210028

出　　处：《四川中医》2017年第6期58-61,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：江苏省科技创新与成果转化专项(编号:BM2009903)

摘　　要：目的:观察云艾散对大鼠胃溃疡愈合的影响作用。方法:健康SD大鼠20只,设正常对照组5只,其余15只复制乙酸性胃溃疡模型,随机分为模型对照组、云艾散组和雷贝拉唑组,各组分别予以蒸馏水、云艾散浓缩药液0.657g/ml、雷贝拉唑混悬液0.18mg/ml各2ml/d灌胃14天,观察各组胃黏膜形态学、病理组织学及血清中表皮生长因子(EGF)、前列腺素E_2(PGE_2)、胃泌素(GAS)表达变化情况。结果:云艾散、雷贝拉唑均能抑制模型大鼠胃黏膜组织损伤,降低溃疡指数,提高溃疡抑制率;两组均能提高血清中EGF含量,抑制GAS表达,与模型对照组比较均具有显著差异(P<0.0.1和0.05);云艾散、雷贝拉唑两组间比较,无显著差异(P>0.05)。结论:云艾散能促进模型大鼠胃溃疡愈合,并能提高愈合质量,其效应与雷贝拉唑相当。Objective ： To observe the effect of Yun＇ai Powder on the healing of gastric ulcer in rats. Methods ： 20 healthy SD rats, randomly accessed 5 was set as the normal controlled group, and the other 15 rats were randomly divided model controlled group, Yun＇ai Powder group and Rabeprazole group by copying the model of gastric ulcer rats, normal controlled group were given standard feeding, other groups were given distilled water 2ml/d, concentrated liquid of Yun＇ai Powder 0. 657g/ml 2ml/d, suspension liquid of Rabeprazole 0. lgmg/ml 2ml/d by gavage for 14d to observe the changes of gastric mucosal mor- phology, histopathology and epidermal growth factor （ EGF）, prostaglandin E2 （ PGE2 ） , gastrin （GAS） expression in serum. Results ： Yun＇ai Powder as well as Rabeprazole were able to control the gastric mucosa damage in model rats, decreased the ulcer index （ P 〈 0. 0. 1 ）, improved the ulcer inhibition rate ; could improve EGF content （ P 〈 0. 01 ） and inhibited the expression of GAS （P 〈 0. 01）, increased PGE2to a certain extent （P 〉 0. 05） in serum, which had significant differences, Compared with the model controlled group （P 〈 0. 0. 1 and 0. 05）. Conclusion ： Yun＇ai Powder can promote the healing of acetic acid induced gastric ulcer in rats and improve the quality of healing, which is comparable to that of Rabeprazole.

关 键 词：胃溃疡 云艾散 溃疡愈合质量 

分 类 号：R285.5[医药卫生—中药学]