低氧诱导因子抑制剂的研究进展  

Advances in the research and development of HIF-1 inhibitors

作　　者：丁凯强[1] 田薇[1] 周德旺[1] 冯爽[1] 杨勇[1] 

机构地区：[1]中国药科大学药物科学研究院,江苏南京211198

出　　处：《药学研究》2017年第6期344-346,372,共4页Journal of Pharmaceutical Research

基　　金：国家自然科学基金青年基金项目(No.81502407);国家自然科学基金(No.81403020);江苏省自然科学基金青年基金项目(No.BK20140666)

摘　　要：低氧诱导因子(hypoxia inducible factor,HIF)是机体的一种重要的转录因子,在缺氧状态下介导一系列的细胞低氧反应。低氧诱导因子在肿瘤发生发展过程中发挥重要调控作用,同时也介导了肿瘤放化疗抗性并与肿瘤患者不良预后密切相关。因此,低氧诱导因子抑制剂的相关研究对于肿瘤的理解与治疗具有重要意义。本文总结了低氧诱导因子抑制剂研究的3种思路与代表抑制剂,以期为低氧诱导因子抑制剂在肿瘤治疗中的应用奠定基础。Hypoxia-inducible factor （HIF） is an essential transcription factor, which mediates a hypoxic response at decreased oxygen tensions.HIF plays vital roles in tumor development and progression and meditates tumor resistance to chemotherapy and radiotherapy and is associated with poor prognosis in cancer patients.Therefore, research and development of HIF inhibitors has the potential to improve treatment efficacy.In this article, three ways of targeting HIF-1 were summarized so as to lay the foundation for the therapeutic use of HIF inhibitors.

关 键 词：低氧诱导因子 缺氧 转录因子 抑制剂 抗肿瘤 

分 类 号：R961[医药卫生—药理学]