早期镇静深度对机械通气患者近期预后影响的应用研究  

A Study of Early Sedation Depth and Short-term Prognosis in Mechanically Ventilated Critically Ill Patients

作　　者：孟祥丽[1] 扈林[1] 

机构地区：[1]山东省邹城市人民医院重症医学科,山东邹城273500

出　　处：《中国医药指南》2017年第12期19-20,共2页Guide of China Medicine

摘　　要：目的探讨早期镇静深度对ICU机械通气的重症患者近期预后的影响。方法 80例重症患者机械通气48 h内进行镇静干预。浅镇静组和深镇静组分别选择右美托咪定和咪达唑仑为镇静药物。比较两组患者机械通气时间、拔管时间、不良事件发生率和ICU住院时间、ICU病死率。结果浅镇静组机械通气时间、拔管时间、ICU住院时间、ICU病死率、物理约束率、谵妄发生率均低于深镇静组,但严重低血压和严重心动过缓发生率高于深镇静组。结论机械通气开始后前48 h的镇静强度与重症患者的近期预后密切相关。Objective To explor the influence of early sedation depth in mechanically ventilated critically ill patients. Methods Sedative to eighty mechanically ventilated critically ill patients in 48 hours. Lihgt sedation group use dexmedetomidine to sedative and deep sedation group use midazolam. To compare the duration of mechanical ventilation, extubation time, incidence of adverse events, ICU mortality and the length of ICU stay of two groups. Results Compared with deep sedation group, the duration of mechanical ventilation, extubation time, ICU mortality and the length of ICU stay in light sedation group is shorter, and the incidence of physical restraints and delirium is lower too. But in light sedation group, the incidence of severe hypotension and severe bradycardia is higher. Conclusions The intensity of sedation in the first 48h after initiation of mechanical ventilation was associated with the short-term prognosis of mechanically ventilated critically ill patients.

关 键 词：早期 镇静深度 机械通气 重症患者 短期预后 

分 类 号：R614[医药卫生—麻醉学]