胶囊型渗透泵控释制剂的研究进展  

Research progress of controlled-release osmotic pump capsules

作　　者：周红[1,2] 胡容峰[2,3,4] 桂赟 金栋[1,2] ZHOU Hong HU Rongfeng GUI Yun JIN Dong(Graduate School of Anhui University of Chinese Medicine, Hefei, Anhui 230012, China Key Laboratory of Xin＇an Medicine Jointly Supported by Ministry of Education and Anhui Province, Hefei, Anhui 230012 , China Anhui ＂ 115＂ Xin/cm Traditional Chinese Medical Research ＆ Development Imiovation Team, Hefei,Anhui 230012 , China Anhui Province Key Laboratory of R＆D of Chinese Medicine,Hefei, Anhui 230012 , China)

机构地区：[1]安徽中医药大学研究生院,安徽合肥230012 [2]省部共建新安医学教育部重点实验室,安徽合肥230012 [3]安徽省“115”新安医药研究与开发创新团队,安徽合肥230012 [4]安徽省中药研究与开发重点实验室,安徽合肥230012

出　　处：《安徽医药》2017年第6期983-986,共4页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金项目(81573615)

摘　　要：渗透泵制剂作为目前应用最广和前景较好的缓控释制剂,具有长时间恒速释药、不受胃肠道因素影响、体内外相关性良好等优点,主要包括片剂、胶囊剂等。与渗透泵片剂相比,渗透泵胶囊具有诸多优势,因而受到药物制剂工作者的广泛关注。该文通过查阅近几年国内外相关文献和专利,分类综述了胶囊型渗透泵控释制剂的研究现状。Osmotic pump preparation is the most widely used sustained-controlled release preparation with good future. It could control drug release with constant speed and avoid the influence from the circumstance of gastrointestinal tract. Besides, the release character in vitro of osmotic pump has good correlation with absorption in vivo. Osmotic pump preparation mainly includes tablets, capsules and so on. Compared with the osmotic pump tablets, osmotic pump capsules have many advantages and have received widespread attention. In this article,the research status of controlled-release osmotic pump capsules is reviewed by retrieving the relevant literature and patents in recent years.

关 键 词：缓控释制剂 恒速释药 渗透泵 胶囊 

分 类 号：R943[医药卫生—药剂学]