替米沙坦联合氨氯地平对老年高血压并左心室肥厚患者的影响  

Impact of Telmisartan Combined with Amlodipine in Treating Elderly Hypertension Patients Complicated with Left Ventricular Hypertrophy

作　　者：苑振飞 李卓隽 高学民[1] 李晓云[1] 刘华[1] 杨小军[1] 

机构地区：[1]河北省唐山市协和医院重症医学科,063000

出　　处：《实用心脑肺血管病杂志》2017年第5期99-101,108,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨替米沙坦联合氨氯地平对老年高血压并左心室肥厚患者的影响。方法选取2013年8月—2015年10月唐山市协和医院收治的老年高血压并左心室肥厚患者126例,采用信封法分为对照组和观察组,每组63例。对照组患者给予氨氯地平治疗,观察组患者给予替米沙坦联合氨氯地平治疗;两组患者均连续治疗6个月。比较两组患者治疗前后血压、心率、超声心动图指标[舒张期室间隔厚度(IVST)、左心室后壁厚度(LVPWT)、左心室舒张末期内径(LVEDD)、左心室质量指数(LVMI)]及血浆内皮素1(ET-1)、N末端B型脑钠肽前体(NT-proBNP)水平,并记录两组患者治疗期间不良反应发生情况。结果两组患者治疗前收缩压、舒张压、心率比较,差异无统计学意义(P>0.05);治疗后观察组患者收缩压、舒张压、心率低于对照组(P<0.05)。两组患者治疗前IVST、LVPWT、LVEDD、LVMI比较,差异无统计学意义(P>0.05);治疗后观察组患者IVST、LVPWT、LVEDD、LVMI低于对照组(P<0.05)。两组患者治疗前血浆ET-1、NT-proBNP水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血浆ET-1、NT-proBNP水平低于对照组(P<0.05)。两组患者治疗期间均未出现严重不良反应。结论替米沙坦联合氨氯地平可有效降低老年高血压并左心室肥厚患者患者血压及血浆ET-1、NT-proBNP水平,逆转左心室肥厚,且安全性较高。Objective To investigate the impact of telmisartan combined with amlodipine in treating elderly hypertension patients complicated with left ventricular hypertrophy. Methods A total of 126 elderly hypertension patients complicated with left ventricular hypertrophy were selected in Xiehe Hospital of Tangshan from August 2013 to October 2015,and they were divided into control group and observation group according to envelope method,each of 63 cases. Patients of control group received amlodipine, while patients of observation group received telmisartan combined with amlodipine; both groups continuously treated for 6 months. Blood pressure,heart rate,echocardiographic index(including IVST,LVPWT,LVEDD and LVMI),plasma levels of ET-1 and NT-proBNP before and after treatment were compared between the two groups, and incidence of adverse reactions was observed during the treatment. Results No statistically significant differences of systolic blood pressure,diastolic blood pressure or heart rate was found between the two groups before treatment(P > 0. 05),while systolic blood pressure,diastolic blood pressure and heart rate of observation group were statistically significantly lower than those of control group after treatment(P < 0. 05). No statistically significant differences of IVST,LVPWT,LVEDD or LVMI was found between the two groups before treatment(P > 0. 05), while IVST, LVPWT, LVEDD and LVMI of observation group were statistically significantly lower than those of control group after treatment(P < 0. 05). No statistically significant differences of plasma level of ET-1 or NT-proBNP was found between the two groups before treatment(P > 0. 05),while plasma levels of ET-1and NT-proBNP of observation group were statistically significantly lower than those of control group after treatment(P < 0. 05).No one of the two groups occurred any serious adverse reactions during the treatment. Conclusion Telmisartan combined with amlodipine can effectively reduce the blood pressure and plasma levels of ET-1 and NT-proBNP,is helpf

关 键 词：高血压 左心室肥厚 替米沙坦 氨氯地平 老年人 治疗结果 

分 类 号：R544.1[医药卫生—心血管疾病]