Recent advances in peptide nucleic acid for cancer bionanotechnology  

作　　者：Jun-chen WU Qing-chun MENG Hong-mei REN Hong-tao WANG Jie WU Qi WANG 

机构地区：[1]Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China [2]Research Institute of Exploration and Development, PetroChina Huabei Oilfield Company, Renqiu 062500, China [3]College of Public Health, Nantong University, Nantong 226019, China

出　　处：《Acta Pharmacologica Sinica》2017年第6期798-805,共8页中国药理学报（英文版）

摘　　要：Peptide nucleic acid （PNA） is an oligomer, in which the phosphate backbone has been replaced by a pseudopeptide backbone that is meant to mimic DNA. Peptide nucleic acids are of the utmost importance in the biomedical field because of their ability to hybridize with neutral nucleic acids and their special chemical and biological properties. In recent years, PNAs have emerged in nanobiotechnology for cancer diagnosis and therapy due to their high affinity and sequence selectivity toward corresponding DNA and RNA. In this review, we summarize the recent progresses that have been made in cancer detection and therapy with PNA biotechnology. In addition, we emphasize nanoparticle PNA-based strategies for the efficient delivery of drugs in anticancer therapiesPeptide nucleic acid （PNA） is an oligomer, in which the phosphate backbone has been replaced by a pseudopeptide backbone that is meant to mimic DNA. Peptide nucleic acids are of the utmost importance in the biomedical field because of their ability to hybridize with neutral nucleic acids and their special chemical and biological properties. In recent years, PNAs have emerged in nanobiotechnology for cancer diagnosis and therapy due to their high affinity and sequence selectivity toward corresponding DNA and RNA. In this review, we summarize the recent progresses that have been made in cancer detection and therapy with PNA biotechnology. In addition, we emphasize nanoparticle PNA-based strategies for the efficient delivery of drugs in anticancer therapies

关 键 词：peptide nucleic acids BIONANOTECHNOLOGY cancer diagnostics and therapy 

分 类 号：Q52[生物学—生物化学] TB383[一般工业技术—材料科学与工程]