Methoxylation and Direct Hydrogenative Coupling of Chloronitrobenzenes in Continuous Flow  

作　　者：Songjie Shi Li Wan Xiaoning Sun Jiawei Zhang Kai Guo 

机构地区：[1]College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China [2]State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, Jiangsu 210009, China [3]Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), 30 Puzhu South Road, Nanjing, Jiangsu 211816, China

出　　处：《Chinese Journal of Chemistry》2017年第4期410-414,共5页中国化学（英文版）

基　　金：This Science work was supported by the National Natural Foundation of China （Nos. 21502090, 21522604）, Natural Science Foundation of Jiangsu Province （Nos. BK20150942, BK20150031） and the National Key Basic Research Program of China （No. 2012CB725204）. We also thank the financial support from Top-notch Academic Programs Project of Jiangsu Higher Education Institutions （TAPP）.

摘　　要：A novel continuous flow method for the methoxylation of chloronitrobenzenes was developed. The reaction went smoothly and high yields were achieved under the optimized conditions. Furthermore, up to 76% yield of azoxybenzenes were obtained from the corresponding nitrobenzenes in the presence of NaOH in continuous flow. Compared to batch conditions, the reaction time was significantly shortened, and the chemical waste was reduced obviously.A novel continuous flow method for the methoxylation of chloronitrobenzenes was developed. The reaction went smoothly and high yields were achieved under the optimized conditions. Furthermore, up to 76% yield of azoxybenzenes were obtained from the corresponding nitrobenzenes in the presence of NaOH in continuous flow. Compared to batch conditions, the reaction time was significantly shortened, and the chemical waste was reduced obviously.

关 键 词：METHOXYLATION AZOXYBENZENES chloronitrobenzenes continuous flow sodium methoxide 

分 类 号：TQ457.2[化学工程—农药化工] TS47[农业科学—烟草工业]