血管内超声评价不同剂量阿托伐他汀对冠状动脉支架内再狭窄的影响  

Effect of High Intensity Statin TheraPy on The Late Lumen Loss of Coronary Stent

作　　者：赵洪磊[1] 龙娟[1] 曾繁芳[1] 陈绮映[1] 罗颖[1] 王丽丽[1] 陈协辉[1] 

机构地区：[1]深圳市孙逸仙心血管医院,广东深圳518112

出　　处：《中国药物经济学》2017年第5期62-64,共3页China Journal of Pharmaceutical Economics

摘　　要：目的观察阿托伐他汀对冠状动脉粥样硬化性心脏病(CHD)患者冠状动脉支架植入术后支架内膜增生的影响。方法选取2014年5月至2016年2月于深圳市孙逸仙心血管医院接受冠状动脉支架植入术治疗的CHD患者117例为研究对象,按照随机数字表法分为观察组58例和对照组59例。所有患者均接收规范的CHD二级预防方案治疗,对照组行常规及阿托伐他汀20 mg,每日1次治疗,观察组行常规及阿托伐他汀40 mg,每日1次治疗,记录两组患者冠状动脉支架植入术后即刻及6~9个月后复查冠状动脉造影时支架内的最小冠状动脉血管直径和内膜增生面积及更少的最小管腔面积。结果两组患者均未发生心脏不良事件和再次支架植入。其中观察组112处病变植入支架,对照组91处病变植入支架,且均完成了造影随访。观察组与对照组支架内晚期管腔丢失和节段内晚期管腔丢失比较差异均有统计学意义(均P<0.05)。观察组的冠状动脉支架内平均内膜增生面积与对照组比较,差异有统计学意义(P<0.05)。结论大剂量阿托伐他汀可以减少冠状动脉支架术后支架内管腔直径丢失和内膜增生,进而预防再狭窄发生。Objective To observe the effect of atorvastatin on the Intimal hyPerPlasia of stent in Patients with coronary heart disease after coronary stent implantation.Methods From May 2014 to February 2016,117 Patients with coronary heart disease were receiving standard scheme and stent imPlantation.Control group with atorvastatin 20mg qd treatment were 59 cases, the study group were 58 cases with atorvastatin：40 mgqd;The minimal lumen diameter（MLD）and intimal hyperplasia area and minimal lumen area of inside stent were recorded after stenting immediately and 6-9 months later.Results Cardiac adverse events and second stent implantations were not occurred in the two groups.The high intensity statin group had 112 lesions were Placed stents,and the control group had 91 stents.High intensity statin therapy group compared with moderate intensity statin theraPy group in stent late lumen loss（P〈0.05）and in segment late lumen loss （P〈0.05）,there were significant differences.The average intimal hyperplasia area was significantly higher than that of moderate intensity statin treatment in the coronary stent, the difference was statistically significant.Conclusion High intensity statins can reduce the diameter of the inner cavity lost after coronary stenting,then can Preventing restenosis.

关 键 词：高强度他汀 冠状动脉造影 晚期管腔丢失 血管内超声 

分 类 号：R541.405[医药卫生—心血管疾病]