硬骨鱼类卵黄原蛋白及其在卵子发生中的作用  

The Vitellogenin and Its Function during Oogenesis in Teleost Fishs

作　　者：周阳[1] 侯聪聪[1] 竺俊全[1] 

机构地区：[1]宁波大学教育部应用海洋生物技术重点实验室浙江省海洋高效健康养殖协同创新中心,宁波315211

出　　处：《中国细胞生物学学报》2017年第5期649-658,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31272642);宁波市科技计划(批准号:2015C110005);浙江省科技计划(批准号:2016C02055-7;2016C32062)资助的课题~~

摘　　要：卵黄原蛋白(vitellogenin,Vtg)作为卵黄蛋白(yolk protein,YP)的前体,参与卵生动物的卵子发生。硬骨鱼类的Vtg为同二聚体,存在不同的亚型,Vtg单体(monomer)由5个结构域组成。在硬骨鱼类卵子发生过程中Vtg主要有两方面作用:(1)Vtg被卵母细胞吸收后裂解为卵黄蛋白,贮存在卵母细胞中,为其生长发育提供必需的营养;(2)随着卵母细胞的发育,卵黄蛋白裂解为游离氨基酸,调节卵母细胞的渗透压,保证水合作用的顺利进行。该文介绍了硬骨鱼类Vtg的种类及结构特性,并对Vtg的表达、吸收、分解及其参与水合作用的研究进展作简要综述,以期为硬骨鱼类卵子发生机制的研究提供参考。Vitellogenin（Vtg）, as the precursor of yolk protein（YP）, involved in the oogenesis in oviparous animals. The structure of teleost fishes’ Vtg is the homodimer and present different subtypes. The Vtg monomer is consist of five different domains. During the oogenesis in teleost, the Vtg plays two functions. On the one hand, the Vtg is hydrolyzed into yolk protein and store in the oocyte to provide the necessary nutrition for the oocyte development. On the other hand, the yolk protein is hydrolyzed into free amino acid with the development of oocyte. These free amino acids can regulate the osmotic pressure of oocyte to ensure the hydration. In this review, we described the types and structural characteristics of teleost Vtg, summarized the recent advances on the expression, uptake, proteolysis, and the role in hydration of Vtg. We hope this review can provide the basic data for the molecular mechanism of teleost fish oogenesis.

关 键 词：硬骨鱼类 卵黄原蛋白 卵黄发生 水合作用 渗透压 

分 类 号：S917.4[农业科学—水产科学]