New cytotoxic apigenin derivatives from Selaginella doederleinii  

作　　者：Zhen-Xing Zou Gui-Shan Tan Guo-Gang Zhang Xia Yu Ping-Sheng Xu Kang-Ping Xu 

机构地区：[1]Xiangya Hospital of Central South University,Changsha 410008,China [2]Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China

出　　处：《Chinese Chemical Letters》2017年第5期931-934,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.31370370);Key Project of Application Technology Research and Development of Haikou(No.2015-039);Project of Strategic Emerging Industry Technology Research and Major Scientific and Technological Achievements of Hunan(No.2015GK1053);Innovation Project for Graduate Students of Hunan(No.CX2013B100)

摘　　要：75%aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated,and two new apigenin derivatives,doederflavones A（1） and B（2）,together with ten known compounds（3-12） were characterized.Their structures were assigned by extensive spectroscopic methods including 1D/2D NMR and HR-ESIMS.Compounds 1-6 bear an aryl substituent at the C-8 or C-6 positions in ring A of apigenin skeleton.Compounds 1 and 2 were evaluated for their in vitro cytotoxicity against four human cancer cell lines A549,MCF-7,SMMC-7721,and LoVo,both of which exhibited significant cytotoxicity against A549 with IC50 values of 0.82 μmol/L and 1.32 μmol/L,respectively.75%aqueous ethanol extract from the whole herbs of Selaginella doederleinii was isolated,and two new apigenin derivatives,doederflavones A（1） and B（2）,together with ten known compounds（3-12） were characterized.Their structures were assigned by extensive spectroscopic methods including 1D/2D NMR and HR-ESIMS.Compounds 1-6 bear an aryl substituent at the C-8 or C-6 positions in ring A of apigenin skeleton.Compounds 1 and 2 were evaluated for their in vitro cytotoxicity against four human cancer cell lines A549,MCF-7,SMMC-7721,and LoVo,both of which exhibited significant cytotoxicity against A549 with IC50 values of 0.82 μmol/L and 1.32 μmol/L,respectively.

关 键 词：Apigenin derivatives Doederflavones A and B Cytotoxicity 

分 类 号：TQ460.1[化学工程—制药化工]