伏格特-小柳-原田综合征脑实质损害症状的临床分析  

Clinical Analysis of Symptoms Associated with Cerebral Parenchyma Injury in Vogt-Koyanagi-Harada Syndrome

作　　者：李琳[1] 王佳伟[1,2] 

机构地区：[1]首都医科大学附属北京同仁医院神经内科,北京100730 [2]首都医科大学附属北京同仁医院中心实验室

出　　处：《中国卒中杂志》2017年第5期396-399,共4页Chinese Journal of Stroke

摘　　要：目的总结伏格特-小柳-原田综合征的神经系统症状损害特点。方法回顾性分析住院伏格特-小柳-原田综合征患者的临床资料,对患者的临床表现、神经系统症状、实验室及磁共振成像(magnetic resonance imaging,MRI)检查结果、治疗等进行描述性分析。结果研究共纳入36例患者,其中30例(83.33%)患者出现神经系统症状,以头痛最为常见(29例,80.56%),卒中样表现包括肢体及面部麻木(1例,2.78%)、步态不稳(1例,2.78%)、意识障碍(1例,2.78%)等。有卒中样症状的患者MRI可见脱髓鞘表现,但未见新发梗死灶。结论伏格特-小柳-原田综合征中可出现脑实质损害症状,在MRI上可表现为脱髓鞘改变。Objective To summarize the clinical characteristics of the nervous system symptoms in patients with Vogt-Koyanagi-Harada syndrome. Methods Clinical materials of the inpatients with Vogt-Koyanagi-Harada syndrome were retrospectively analyzed. The clinical features, nervous system symptoms, results of lab tests and magnetic resonance imaging （MRI）, treatment and prognosis were descriptively analyzed. Results Thirty-six cases were collected, of which 30 （83.33%） cases presented with nervous system symptoms, and headache was the most common （29 cases, 80.56%）. Stroke-like symptoms included limbs and facial numbness （1 case, 2.78%）, walking unstable （1 case, 2.78%）, conscious disturbance （1 case, 2.78%）. Demyelination sign can be seen on the MRI of the patients with stroke-like symptoms, yet without new infarction lesion. Conclusion Symptoms associated with cerebral parenchyma injury are uncommon in patients with Vogt-Koyanagi-Harada syndrome, presenting demyelination sign on MRI.

关 键 词：伏格特-小柳-原田综合征 神经系统 卒中 

分 类 号：R593.2[医药卫生—内科学] R747.9[医药卫生—临床医学]