中药质量标志物与“网通虹势”代谢规律  

Q-marker of Chinese medicine and metabolic regularity of co-network compatibility and rainbow potential

作　　者：杨岩涛[1,2,3,4] 李森[1,4] 刘金玲[1,4] 周晋[1,3,4] 周逸群[1,3,4] 陈乃宏[1,2] 贺福元[1,3,4] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050 [3]中药成药性与制剂制备湖南省重点实验室,湖南长沙410208 [4]湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208

出　　处：《中国中药杂志》2017年第12期2420-2424,共5页China Journal of Chinese Materia Medica

基　　金：天然药物活性物质与功能国家重点实验室开放课题(GTZK201607);湖南省教育厅优秀青年基金项目(2015B172);湖南省中医药科研基金项目(201494);湖南省教育厅一般项目(2015C1039);湖南省"十二五"省级药学重点学科(1007)开放基金项目

摘　　要：中药复方疗效是建立在单味中药基础上按中医药基础理论依法遣药组方治病的结果,其作用体现多成分、多靶点、综合效应的特点,其物质基础研究不易,质量标准难以建立,质量标志物难确定,无法严格监控中药加工全过程中的质量,且中药标志物的确定对中药药效物质研究、中药材鉴别及中药制药工程等影响深远;中药与生物体的"网通虹势"代谢规律将中药多成分的零散作用规律视为同母核群体的整体作用,可沟通微观单成分个体与宏观成分群整体,揭示中药在生物体内代谢物质、信息交流基本规律,进而揭示中药复方对人体的作用规律。通过系统分析中药质量标志物对中药开发的指导作用及其与"网通虹势"代谢规律的关系,尝试为中药质量标志物的确定提供思路。The effect of Chinese medicine （CM） compound prescription is the combined action results of single herbs based on the basic theory of Chinese medicine, and its function embodies the characteristics of multi components, multi targets and comprehensive effects. It is difficult to study the therapeutic material, establish quality standards or determine Q-marker, so we can＇t strictly monitor the quality of the whole process of CM. The identification of Q-marker has a profound influence on the whole process of the pharmaceu- tical engineering of CM. The scattered effect of CM multi-components is regarded as the integral action of the parent nucleus group by the metabolic rule of co-network compatibility and rainbow potential （CCRP）. The rule can be used to communicate the individual components and macro components, to reveal the metabolism of CM in organism body and basic law of information exchange, thus re- vealing the action law of CM on human body. Through the systematic analysis of the Q-marker＇s guidance to the development of CM and its relationship with the metabolic rule of CCRP, we try to provide some ideas for the identification of Q-marker.

关 键 词：中药质量标志物 网通虹势 药效物质 质量 

分 类 号：R28[医药卫生—中药学]