丁螺环酮联合帕罗西汀治疗焦虑症的疗效观察  

Observation on Efficacy of Buspirone Combined with Paroxetine in Treatment of Anxiety Disorders

作　　者：李鹏辉[1] 王文军[1] 卢全恩 苏金哥 李伟民[1] 

机构地区：[1]惠州市第二人民医院精神科,广东惠州516000 [2]惠州市复员退伍军人医院精神科,广东惠州516001

出　　处：《中国医院用药评价与分析》2017年第5期656-657,660,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:观察丁螺环酮联合帕罗西汀治疗焦虑症的临床疗效及安全性。方法:选取2015年1月—2016年1月惠州市第二人民医院收治的焦虑症患者86例作为研究对象,按照入院顺序,单号纳入观察组,双号纳入对照组,每组43例。观察组患者采用丁螺环酮联合帕罗西汀治疗,对照组患者采用丁螺环酮单药治疗,治疗3个月为1个疗程。采用汉密尔顿焦虑量表评分减分率评定两组患者的临床疗效,并比较两组患者药品不良反应发生情况。结果:观察组患者总有效率为95.35%(41/43),明显高于对照组的83.72%(36/43),差异有统计学意义(P<0.05);两组患者不良反应发生率的差异无统计学意义(P>0.05)。结论:采用丁螺环酮联合帕罗西汀治疗焦虑症,有利于缓解患者的焦虑症状,疗效显著,且不良反应较少。OBJECTIVE ：To observe the clinical efficacy and safety of buspirone combined with paroxetine in treatment of anxiety disorders. METHODS： 86 patients with anxiety disorders admitted into Huizhou the Second People＇ s Hospital from Jan. 2015 to Jan. 2016 via the admission sequence, with 43 cases in each group. The observation group was given buspirone combined with paroxetine, while the control group was treated with buspirone alone, 3 month of treatment was set as a course. Score-reducing rate of Hamilton Anxiety Scale was adopted to evaluate the clinical efficacy of two groups, and the adverse drug reactions of two groups were compared. RESULTS： The total effective rate of observation group（95. 35%, 41/43） was significantly higher than that of the control group （83. 72%, 36/43）, with statistically significant difference （P 〈 0. 05）. There was no statistical difference in the incidence of adverse drug reactions between two groups （P 〉 0. 05 ）. CONCLUSIONS： The clinical efficacy of buspirone combined with paroxetine in treatment of anxiety disorders was significant, which benefits to relieve patients＇ anxiety with less adverse drug reactions.

关 键 词：焦虑症 丁螺环酮 帕罗西汀 临床疗效 

分 类 号：R971[医药卫生—药品]