双歧杆菌三联活菌对急性胰腺炎血清内毒素、TNF-α及D-乳酸水平的影响  

Effect of Bifidobacterium Triple Live Bacteria on Serum Endotoxin,TNF-α and D-lactic Acid in Patients with Acute Pancreatitis

作　　者：王丽[1] 白晓黎[1] 杜娟[1] 

机构地区：[1]河南科技大学第一附属医院,河南洛阳471003

出　　处：《河南科技大学学报（医学版）》2017年第2期124-125,128,共3页Journal of Henan University of Science & Technology:Medical Science

摘　　要：目的观察双歧杆菌三联活菌片对急性胰腺炎肠黏膜屏障功能的影响。方法本院2015年1月至2017年1月收治的急性胰腺炎68例,随机分为对照组和观察组各34例。两组均实施常规治疗,观察组在此基础上加用双歧杆菌三联活菌,比较两组疗效及血清内毒素、TNF-α及D乳酸水平等肠黏膜屏障功能改善情况。结果治疗7 d后,两组血清内毒素、TNF-α及D乳酸水平均较治疗前明显减少(均P<0.05),且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率94.12%高于对照组的73.53%,差异有统计学意义(P<0.05)。结论双歧杆菌三联活菌片治疗急性胰腺炎,可降低血清内毒素、TNF-α及D乳酸水平,明显改善肠黏膜屏障功能。Objective To observe the effect of bifidobacterium triple live bacteria on intestinal mucosal barrier function in patients with acute pancreatitis. Methods 68 patients with acute pancreatitis treated in our hospital were analyzed retrospectively from January 2015 to January 2017. According to the random number table method, all patients were divided into the control group and the observation group, 34 cases per group. Two groups were treated with conventional treatment, and the observation group was adding bifidobacterium triple live bacteria. Therapeutic effect and intestinal mucosal barrier function were compared between two group. Results After 1 week of treatment, the levels of serum endotoxin, TNF-α and D-lactic acid were significantly lower than those before treatment（all P 〈 0.05） , and the observation group level was lower than the control group （P 〈 0.05） . The total effective rate of the observation group 94.12% was higher than the control group 73.53% （ P 〈 0.05 ）. Conclusion Bifidobacterium triple live bacteria treating patients with acute pancreatitis could reduce the levels of serum endotoxin, TNF-α and D-lactic acid and improve the function of intestinal mucosal barrier.

关 键 词：急性胰腺炎 双歧杆菌三联活菌片 肠黏膜 

分 类 号：R975.3[医药卫生—药品]