深圳市龙岗区18711例1～14岁儿童血清乙肝表面抗体水平分析  

Serum anti-HBs levels in children aged from 1 to 14 years old in Longgang District of Shenzhen city

作　　者：夏洪波[1] 邢萌萌[1] 任路忠[1] 马杰彦 

机构地区：[1]广东省深圳市龙岗区妇幼保健院,广东深圳518172

出　　处：《中国农村卫生事业管理》2017年第5期564-567,共4页Chinese Rural Health Service Administration

摘　　要：目的:了解深圳市龙岗区1~14岁儿童血清抗-HBs水平现况,为进行儿童抗-HBs水平监测及加强免疫决策提供依据。方法:选取2012年1月-2016年7月在深圳市龙岗区妇幼保健院儿童保健科健康体检并完成0、1、6个月基础免疫的18 711名1~14岁儿童作为研究对象,抽取静脉血3ml,采用ELISA法检测血清抗-HBs水平。结果:18 711名1~14岁儿童血清抗-HBs阳性率为59.25%;其中女童血清抗-HBs阳性率为61.39%,高于男童的57.57%,差异具有统计学意义(χ~2=27.93,P=0.000)。不同年龄组间儿童血清抗-HBs阳性率不同,差异具有统计学意义(χ~2=13 48.2,P=0.000)。幼儿组儿童血清抗-HBs阳性率最高为71.26%,在1岁左右达到78.65%;随后儿童血清抗-HBs阳性率随时间推移而下降,学龄前组儿童最低为48.67%。结论:龙岗区1~14岁儿童HBV感染流行趋势处于较低水平,但抗-HBs阳性率仅为59.25%,为规避儿童个体感染HBV的风险,需要加强儿童血清HBV感染的免疫监测,对于抗-HBs无/低应答儿童应再次免疫接种。Objective To investigate the level status of serum anti--HBs in children aged from 1 to 14 years old in Longgang District of Shenzhen city,and to provide basis for monitoring anti--HBs levels and strengthening children＇s immunity decision--making. Methods Totally 18711 children aged from 1 to 14 years were enrolled in this study who had accepted the 0,1,6-month basic immunization in Longgang Maternal and Child Health Care Center from January 2012 to July 2016,and the serum anti--HBs levels of them were detected by ELISA method. Results The positive rate of serum anti--HBs of the 18 711 children was 59.25% ,and the rate of girls was 61.39% ,higher than that of boys （57.57 %）, and there was statistically significant difference between girls and boys（χ^2= 27.93, P=0. 000）. The positive rates of serum anti--HBs in different age groups were different,and there was statistically significant difference among different age groups（χ^2 = 1 348.2, P= 0. 000）. The positive rate of infant group was the highest（71.26 %）, especially for the children aged 1 year old（78.65%）,and the positive rate was gradually decreased along with the increasing age of the children. So the positive rate of the preschool children was the lowest（only 48.67%）. Conclusions The prevalence of HBV infection in children aged from 1 to 14 years in Longgang District is at a low level,however,the positive rate of anti--HBs is only 52.95% ,so it is necessary to strengthen the immunological monitoring of HBV infection and enhance revaccination for children whose anti- HBs were negative or weak positive to protect children from HBV infection.

关 键 词：儿童 抗-HBS HBV 免疫监测 

分 类 号：R186[医药卫生—流行病学]