机构地区:[1]遵义医学院附属医院重症医学科,贵州遵义563003
出 处:《中国中西医结合急救杂志》2017年第3期234-238,共5页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基 金:国家自然科学基金面上项目(81560308)
摘 要:目的 探讨黔北地区7年来重症急性胰腺炎(SAP)的流行病学特点及其并发症对预后的影响.方法 回顾性分析遵义医学院附属医院重症医学科2009年1月至2016年1月收治的209例SAP患者的临床资料,按预后将其分为生存组(178例)与死亡组(31例),比较两组性别、年龄、诊断(初发、复发)、住院时间、肌酐、总胆红素(TBil)、血液净化时间、入院1 d血细胞比容(HCT)、病因、并发症〔感染、假性囊肿、腹腔内出血、急性肾损伤(AKI)、急性肾衰竭(ARF)、急性呼吸窘迫综合征(ARDS)、腹腔间隔室综合征(ACS)、胰性脑病、多器官功能障碍综合征(MODS)〕、序贯器官衰竭评分(SOFA)评分(住院期间最高SOFA的评分)、使用激素、外科手术干预等的差异,分析重症加强治疗病房(ICU)SAP的流行病学特点及影响预后的危险因素.结果 209例SAP患者中胆源性胰腺炎98例(占46.9%),高脂血症性胰腺炎76例(占36.3%),酒精性胰腺炎6例(占2.8%)、特发性胰腺炎29例(占13.9%).生存组年龄(岁:47.1±13.5比53.2±12.0)、肌酐水平(μmol/L:109.4±100.3比335.7±222.4)以及发生腹腔内出血〔4.5%(8)比38.7%(12)〕、ARF〔1.1%(2)比54.8%(17)〕、ACS〔1.1%(2)比9.7%(3)〕、MODS〔18.5%(33)比74.2%(23)〕的比例和SOFA评分(分:3.3±2.4比10.5±5.4)及激素使用率〔5.6%(10)比29.0%(9)〕均较死亡组明显降低(均P〈0.05),血液净化时间较对照组缩短(d:1.95±1.97比4.81±5.84);两组性别、诊断、住院时间、TBil、入院第1天HCT、病因、并发症(感染、假性囊肿、ARDS、胰性脑病)、手术情况比较差异均无统计学意义(均P〉0.05).Logistic回归分析显示,肌酐〉300μmol/L〔优势比(OR)为2.651,95%可信区间(95%CI)为1.459~3.935,P=0.017〕、腹腔内出血(OR为5.231,95%CI为3.517~7.159,P=0.000)、有ARF(OR为3.73Objective To investigate the epidemiologic characteristics of patients with severe acute pancreatitis (SAP) and the effects of its complications on prognoses in past 7 years in the north area of Guizhou province. Methods Data of 209 patients with SAP admitted to the Department of Critical Care Medicine of Affiliated Hospital of Zunyi Medical College from January 2009 to January2016 were retrospectively analyzed, and they were divided into a survival group (178 cases) and a death group (31 cases) according to the prognosis. The gender, age, diagnosis (primary and recurrent), the length of stay in hospital, the levels of creatinine and total bilirubin (TBil), the time of blood purification, hematocrit (HCT) level on the first day after admission, pathogenesis, complications [infection, pseudocyst, intra-peritoneal hemorrhage, acute renal failure (ARF), acute respiratory distress syndrome (ARDS), abdominal compartment syndrome (ACS), pancreatic encephalopathy, multiple organ dysfunction syndrome (MODS)], sequential organ failure (SOFA) score (maximum SOFA score during hospital stay), application of hormones, surgical interference, etc. related factors were compared, the SAP epidemiological characteristics, factors affecting prognosis and the effect of complications on prognosis in intensive care unit (ICU) were analyzed in the two groups.Results Of the 209 patients 98 cases were diagnosed biliary pancreatitis accounting for the majority (46.9%), hyperlipidemic pancreatitis 76 cases (36.3%), alcoholic pancreatitis 6 cases (2.8%) and idiopathic pancreatitis29 cases (13.9%). The age (years: 47.1±13.5 vs. 53.2±12.0), creatinine (μmol/L: 109.4±100.3 vs. 335.7±222.4), the ration of intra-peritoneal hemorrhage [4.5% (8) vs. 38.7% (12)], ARF [1.1% (2) vs. 54.8% (17)], ACS [1.1% (2) vs. 9.7% (3)], MODS [18.5% (33) vs. 74.2% (23)] and SOFA score (3.3±2.4 vs. 10.5±5.4), percentage of patients us
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