MicroRNA对药物转运体调控的研究现状  

Research status on microRNA-dependent control of drug transporters

作　　者：靳高凤 熊玉卿[1,2] 

机构地区：[1]南昌大学临床药理研究所,南昌330006 [2]江西省临床药物代谢动力学重点实验室,南昌330006

出　　处：《中国临床药理学杂志》2017年第11期1061-1064,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81260508);江西省"赣鄱英才555工程"人才资助计划基金资助项目(18000046);江西省研究生创新专项资金资助项目(YC2015-B005)

摘　　要：MicroRNA作为一类重要的功能性非编码RNA,主要通过与靶基因mRNA3'端非编码区的互补结合来调节其表达。MicroRNA既可以直接靶向药物转运体的mRNA,继而调控其表达,亦可通过调节某些经典通路的信号蛋白,间接调控转运体的表达。因此,本文系统地综述了近年来microRNA对几种重要药物转运体调控的研究进展。MicroRNA is a class of small noncoding single-stranded molecule RNA,which regulates the expression of target genes through binding with the 3’-untranslated region of target gene mRNA.In recent years,researches about microRNA regulating transporter have attracted widespread attention.With more in-depth researches,it was found that not only can microRNA directly target the mRNA of transporters,but also it can regulate some signal proteins of classic pathway to control the expression of transporters indirectly.This review summarizes the research progress of microRNAs on the regulations of several important transporters.

关 键 词：微小RNA 药物转运体 腺苷三磷酸结合盒转运蛋白 溶质载体 转录后调控 

分 类 号：R97[医药卫生—药品]