脑脊液和血清中PCT与NSE及CRP检测在颅内感染诊断中的价值分析  

Analysis of the value of cerebrospinal fluid and serum PCT,NSE and CRP detection in the diagnosis of intracranial infection

作　　者：乔潜林[1] 白新学[1] 刘海玉[1] 马新强[1] 赵墨[1] 

机构地区：[1]南阳市中心医院神经外科,河南南阳473000

出　　处：《中华医院感染学杂志》2017年第11期2469-2472,共4页Chinese Journal of Nosocomiology

摘　　要：目的观察颅内感染患者脑脊液和血清中降钙素原(PCT)、神经元特异性烯醇化酶(NSE)、C-反应蛋白(CRP)的表达特点,初步分析检测血清PCT、NSE、CRP对颅内感染的诊治价值。方法选取2012年4月-2015年10月在医院行开颅手术后并发颅内感染的90例患者为观察组,将无颅内感染、资料相匹配的30例患者为对照组,对比分析两组患者血清和脑脊液PCT、NSE、CRP的表达特征。结果颅内感染各组患者的血清和脑脊液PCT、NSE、CRP水平显著高于对照组,且化脓性组患者PCT、CRP水平显著高于其他两组感染患者,而病毒性组NSE水平显著高于其他两组感染患者,各组间检测结果差异有统计学意义(P<0.05);颅内感染昏迷组患者PCT、NSE和CRP水平均显著高于对照组和未昏迷组,且未昏迷组上述指标显著高于对照组,各组间PCT、NSE和CRP表达差异有统计学意义(P<0.05)。结论脑脊液和血清PCT、NSE、CRP表达水平在一定程度上能够反应颅内感染的病情严重程度,对于颅内感染鉴别诊断和病情评估具有参考价值。OBJECTIVE To observe the expression characteristics of cerebrospinal fluid and serum procalcitonin （PCT）,neuron-specific enolase （NSE）,and C-reactive protein （CRP） in patients with intracranial infection and to analyze the diagnostic value of serum PCT,NSE and CRP in intracranial infection.METHODS A total of 90 patients with intracranial infection after craniotomy in our hospital from Apr.2012 to Oct.2015 were chosen as observation group,and another 30 patients without intracranial infection and matched data were taken as control group.The expression characteristics of PCT,NSE and CRP in serum and cerebrospinal fluid of the two groups were compared and analyzed.RESULTS The levels of PCT,NSE and CRP in serum and cerebrospinal fluid of patients with intracranial infection were significantly higher than those in control group,the levels of PCT and CRP in serum and cerebrospinal fluid of purulent group were significantly higher than those of other groups,and the serum and cerebrospinal fluid NSE levels in viral group were significantly higher than those in other groups （P〈0.05）.The levels of PCT,NSE and CRP in serum and cerebrospinal fluid of coma patients were significantly higher than those of control group and non-coma group,and the above indexes in non-coma group were significantly high-er than those in control group,and there were significant differences in PCT,NSE and CRP expressions among different groups （P〈0.05）.CONCLUSION The expression levels of PCT,NSE and CRP in blood and cerebrospinal fluid can reflect the severity of intracranial infection in a certain extent,which have reference value for the differential diagnosis and evaluation of intracranial infection.

关 键 词：脑脊液 血清 降钙素原 神经元特异性烯醇化酶 C-反应蛋白 颅内感染 

分 类 号：R446[医药卫生—诊断学]