血液科住院患者慢性乙型肝炎感染状况研究  

Chronic hepatitis B infection among inpatients in department of hematology

作　　者：鲍丽彦[1] 黄建新[1] 陈丹[1] 史科其[1] 梅丽娜 

机构地区：[1]慈溪市人民医院血液内科综合内科,浙江慈溪315300 [2]湖州市妇幼保健医院消化内科,浙江湖州313000

出　　处：《中华医院感染学杂志》2017年第11期2495-2497,2527,共4页Chinese Journal of Nosocomiology

摘　　要：目的探究血液科住院患者被病毒感染而导致慢性乙型肝炎的情况,提高住院患者慢性乙型肝炎病毒感染的认知。方法选择2012年3月-2016年5月于医院血液科治疗123例患者,将其分为住院慢性乙型肝炎组84例,肝硬化组21例和并发肝癌组18例,比较分析其临床资料。结果住院慢性乙型肝炎组84例患者中,40~49岁患者有26例占31.0%,以男性患者为主,69例占82.1%;住院慢性乙型肝炎组患者病程<3年54例占64.3%,肝硬化组患者病程为5~10年12例占57.1%,并发肝癌组患者病程>10年以上10例占55.6%;住院慢性乙型肝炎组患者血小板含量以150×10~9/L以上为主,有37例占44.1%,肝硬化组患者以50~100×10~9/L为主,有14例占66.7%,并发肝癌组患者以100~150×10~9/L为主,有7例占38.9%;慢性乙型肝炎主要临床表现为乏力57例(67.9%)及纳差症状41例(48.8%);非血液科患者216例中HBsAg阳性患者23例,阳性率10.6%,37例再障患者中HBsAg阳性10例,阳性率27.0%。结论血液科住院慢性乙型肝炎患者发病年龄多在40~59岁之间,血小板含量大多在100×10~9/L以上,再障血液病患者HBsAg阳性率最大,骨髓瘤血液病患者HBsAg阳性率最低。OBJECTIVE To explore the situation of patients with chronic hepatitis B virus infection caused by virus infection in the department of hematology,and improve the cognition of chronic hepatitis B virus infection of inpatients.METHODS A total of 123 cases of infected patients treated in the department of hematology from Mar.2012 to May 2016 were selected,and were divided into hospitalized chronic hepatitis B virus infection group with 84 cases,cirrhosis group with 21 cases and complications of liver cancer group with 18 cases.The clinical data of the groups were compared and analyzed.RESULTS Among the 84 patients with chronic hepatitis B virus infection,26 patients （31.0%） were aged 40-49 years,and 69 cases were males （82.1%）.Totally 54 cases ofinpatients with chronic hepatitis B were treated less than 3 years（64.3%）,12 patients with cirrhosis were treated 5-10 years （57.1%）,and 10 patients with hepatocellular carcinoma were mainly treated more than 10 years（55.6%）.The platelet content in patients with chronic hepatitis B was mainly more than 150× 109/L,which was 37 cases （44.1%）,in liver cirrhosis patients was mainly 50 100×109/L,which was 14 cases （66.7%）,and in liver cancer patients was mainly 100-150× 109/L,which was 7 cases （38.9%）.The main clinical manifestations of chronic hepatitis B were fatigue and anorexia symptoms,which were 57 cases （67.9%） and 41 cases （48.8%）,respectively.There were 23 cases （10.6 %） of HBsAg positive patients in the 216 cases of patients with non-hematologic diseases,and 10 cases （27.0%） of HBsAg positive patients in 37 cases of patients with aplastic anemia.CONCLUSION In patients with chronic hepatitis B in departmcnt of hematology,the incidence of chronic hepatitis B are mainly between 40 and 59 years old,then platelet content are mostly more than 100）〈 109/L,aplastic anemia patients have the highest HBsAg positive rate,and myeloma hematological malignancies have the lowest HBsAg positiverate.

关 键 词：慢性乙型肝炎 住院患者 感染状况 

分 类 号：R512.62[医药卫生—内科学]