基于Wnt/β-链蛋白表达评价丹蛭降糖胶囊对2型糖尿病患者血管的保护作用  

Danzhijiangtang capsule protects vasculopathy of T2DM: an evaluation based on the expression of Wnt/β-catenin

作　　者：倪英群[1] 谢峰涛 方朝晖[1] 

机构地区：[1]安徽中医药大学安徽省中医院 [2]安徽中医药大学

出　　处：《中国临床药理学与治疗学》2017年第5期531-537,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家科技部国家科技支撑计划(2012BA126B00);国家中医药管理局国家基本公共卫生服务项目(20131012);安徽省高校自然科学研究项目(KJ2015A136);国家自然科学基金立项项目(81573944);安徽省卫生计生委中医药科研课题(2016zy73)

摘　　要：目的:通过观察丹蛭降糖胶囊对2型糖尿病患者大血管Wnt/β-链蛋白(Wnt/β-catenin)、糖原合成酶激酶-3(GSK-3β)通路表达,以及对颈动脉内膜中层厚度(IMT)和斑块面积的影响,评价丹蛭降糖胶囊对2型糖尿病患者大血管病变的保护作用。方法:将102例2型糖尿病患者随机分为对照组和治疗组各51人。所有患者给予基础药物(常规口服降糖药物)治疗,治疗组采用基础药物+丹蛭降糖胶囊,疗程均为16周。结果:16周后治疗组总有效率84.31%,优于对照组的64.71%,差异有统计学意义(P<0.05);两组治疗前后比较中医证候积分、FPG、2 h PG、Hb A1c、TC、TG、LDL、HDL、颈动脉IMT及斑块面积水平都有所改善(P<0.05或P<0.01);组间比较,治疗组中医证候积分、2 h PG、Hb A1c、TG及LDL水平下降,具有统计学差异(P<0.05或P<0.01);治疗组IMT改善情况优于对照组(P<0.05),但斑块面积改善情况无统计学意义(P>0.05)。治疗后,治疗组血清β-catenin水平较对照组显著降低(P<0.01),血清GSK-3β水平比对照组降低,差异有统计学意义(P<0.05)。结论:丹蛭降糖胶囊可以显著缓解2型糖尿病患者临床症状,并在一定程度上改善或逆转颈动脉硬化进程。AIM： To evaluate the protective effect of Danzhijiangtang capsule on vasculopathy of type 2 diabetes mellitus （T2DM） patients by observ- ing the expression of Wnt/^-catenin, GSK-3 6, and the change of carotid intima media thickness （IMT） and plaque area. METHODS： One hundred and two T2DM patients were randomly allocated into the control group and the treatment group （n = 51 ）. Both groups received conventional therapy （hypogly- cemic drugs orally）, while the treatment group was given extra Danzhijiangtang capsule. Therapy was conducted for 16 weeks. RESULTS：The total effec- tive rate of the treatment group was significantly bet- ter than that of the control group （84.31% vs. 64.71%, P 〈0.05）. Traditional Chinese Medicine （TCM） symptom scores, FPG, 2 hPG, HbAlc, TC, TG, LDL, HDL, carotid intima media thick-ness and plaque area were improved in both groups. Compared with the control group, TCM scores, 2 hPG, HbA1, TG and LDL decreased significantly （P 〈 0.05 or P 〈 0.01） in the treatment group, which also presented better improvement of IMT （P 〈 0.05 ） though the comparison of plague area ex- hibited no significant difference （ P 〉 0.05 ） ; The expressions of Wnt/β-catenin and GSK-3β also decreased significantly in the treatment group （P 〈 0.05 ）. CONCLUSION ： Danzhijiangtang capsule can alleviate the clinical symptoms of T2DM, and can improve or even reverse carotid atherosclerosis to a certain extent.

关 键 词：2型糖尿病 血管病变 丹蛭降糖胶囊 Wnt/β-链蛋白 糖原合成酶激酶-3 

分 类 号：R969.1[医药卫生—药理学]