2010-2014年唐山市放射工作人员外周血淋巴细胞染色体畸变和微核率分析  

Analysis of chromosomal aberration and micronucleus rate of peripheral blood lymphocytes of radiation workers in Tangshan City during 2010-2014

作　　者：苑森梅 杜胜强 王晓红[2] 肖淑玉[2] 沈福海[1] 胡江 

机构地区：[1]华北理工大学公共卫生学院,河北省煤矿卫生与安全实验室,河北唐山063000 [2]唐山市疾病预防控制中心,河北唐山063000 [3]唐山市食品药品监督管理局稽查局,河北唐山063000

出　　处：《职业与健康》2017年第8期1041-1043,共3页Occupation and Health

基　　金：唐山市科技局科研项目(09130223a)

摘　　要：目的通过调查唐山市放射工作人员外周血淋巴细胞染色体畸变率和微核率,了解放射防护工作情况。方法对2010、2012、2014年唐山市放射工作人员职业健康检查结果中染色体和微核率进行分析,采用外周血淋巴细胞常规培养法,利用χ~2检验分别对放射工作人员进行染色体畸变与微核率的统计学分析。结果 2010—2014年放射工作人员染色体畸变率和微核率的年度间差异均有统计学意义;医学应用组微核异常率,染色体畸变率最高;工龄10~<20 a组和>20 a组放射工作人员微核异常率高于<10 a组。结论小剂量电离辐射对放射工作人员的遗传物质有一定损伤,但这种损伤逐年下降。医学应用组和中高放射工龄人员是防护的重点人群。[ Objective ] To investigate the situation of radiation protection via the investigation on the rate of chromosome aberra- tion and mieronueleus rate of peripheral blood lymphocytes of radiation workers in Tangshan City. [Methods] The chromosome and micronueleus rates of 2010,2012,2014 occupational health examination results were analyzed by routine peripheral blood lymphocyte culture method, using X2 test for statistical analysis of chromosomal aberration and micronueleus rate of radiation work- ers,respeetively.[Results] The difference of chromosome aberration rate and micronucleus rate of radiation workers from 2010- 2014 was statistically significant between years. In medical application group,the abnormal rate of micronucleus and the rate of chromosome aberration was the highest. The abnormal mieronueleus rate of 10-〈20 years and 〉20 years age group was higher than that of the 〈10 years age group. [Conclusion] The analysis shows that the low dose ionizing radiation has a certain damage to the genetic material of radiation workers, but the damage is decreasing year by year. Medical application group and workers with high radiation length of service are the key groups for protection.

关 键 词：电离辐射 放射工作人员 染色体畸变率 微核率 

分 类 号：R146[医药卫生—公共卫生与预防医学]