奥沙利铂神经毒性机制及防治新进展  

New Progress in the Pathogenesis and Treatment of Oxaliplatin Induced Neurotoxicity

作　　者：谷麟[1] 李雪松[1] 刘东[2] 邓丽[2] 王丽[3] 宋秋艳[3] 张程亮[2] 

机构地区：[1]昆明医科大学第一附属医院药剂科,昆明650032 [2]华中科技大学同济医学院附属同济医院药学部 [3]玉溪市人民医院药学部

出　　处：《药物流行病学杂志》2017年第6期429-435,共7页Chinese Journal of Pharmacoepidemiology

基　　金：湖北省药品(医疗器械)不良反应监测中心课题(编号:20160422)

摘　　要：奥沙利铂的神经毒性是其常见不良反应之一,具有独特的临床特征,其发生机制至今尚不清楚并且缺乏有效的防治方法。近年来的研究发现,瞬时受体电位通道、间隙连接通道、烟碱型乙酰胆碱受体等在介导奥沙利铂神经毒性中发挥了重要作用,基因多态性也与其显著相关。此外,研究者们利用锰福地吡、单唾液酸神经节苷脂和黄芪根提取物等药物在防治奥沙利铂的神经毒性中进行了探索,并显示出了良好的疗效。该文就近年来奥沙利铂神经毒性的发生机制及防治研究进展做一综述。Oxaliplatin induced neuropathy, which had unique clinical features, was one of the most common ad- verse effects associated with oxaliplatin administration. The exact mechanism of oxaliplatin-induced nettrotoxicity was not known and no effective prevention and treatment methods had been developed. Several recent studies had found that transi- ent receptor potential channels, gap junction channels, nicotinic-aeetylcholine-receptors and so on may mediate the neuro- toxicity of oxaliplatin, with which genetic polymorphisms were also significantly associated. Mangafodipir, ganglioside- monosialic acid, and Astragali radix extracts and so on had shown preventive and therapeutic effects in clinical studies. In this article, new progress in the pathogenesis and treatment of oxaliplatin induced neurotoxicity were reviewed.

关 键 词：奥沙利铂 神经毒性 神经病变 

分 类 号：R979.11[医药卫生—药品]