血清胆红素、胆汁酸水平与糖尿病大血管病变的关系研究  

Research on Correlation between Serum Bilirubin, Bile Acid Level and Diabetic Macroangiopathy

作　　者：朱蕾[1] 

机构地区：[1]成都市第七人民医院检验科,四川成都610041

出　　处：《糖尿病新世界》2017年第6期11-13,共3页Diabetes New World Magazine

摘　　要：目的探讨2型糖尿病(T2DM)患者血清总胆红素、血清总胆汁酸水平与糖尿病大血管病变之间的关系。方法纳入该院60例确诊为T2DM患者,以存在高血压病、冠心病、脑血管病以及下肢缺血性病变之一或其中几项者作为合并大血管病变的依据。其中合并大血管病变(A组)30例,无大血管病变(B组)30例,另纳入30名同期查体健康成人作为对照组(C组)。观察3组之间血清总胆红素、血清总胆汁酸的差异,探讨血清总胆红素、血清总胆汁酸与低密度脂蛋白胆固醇(LDL-C)之间的线性相关关系。结果 A组患者的血清总胆红素和血清总胆汁酸均低于B、C组(P<0.05)。3者之间进行线性相关分析,血清总胆红素和血清总胆汁酸具有明显正相关(r=0.763 2);血清总胆红素、血清总胆汁酸与低密度脂蛋白胆固醇分别具有明显负相关(r=-0.950 5;r=-0.956 6)。结论血清总胆红素和血清总胆汁酸可能对T2DM患者的大血管具有保护作用,对于预防和减缓糖尿病大血管病变恶化具有重要临床指导意义。Objective To study the correlation between serum bilirubin, bile acid level and diabetic macroangiopathy. Methods 60 cases of T2DM patients were confirmed and divided into two groups with 30 cases in each according to whether the macroangiopathy including hypertension, coronary heart disease, cerebrovascular disease or lower extremity ischemic infarct or not, the patients with macroangiopathy were the group A and the patients without macroangiopathy were the group B, and 30 cases of health adults were selected as the control group （ group C）, and the total serum bilirubin and total serum bile acid level of the three groups were observed and the liner relationship between the total serum bilirubin, total bile acid and LDL-C was studied. Results The serum bilirubin and total serum bile acid levels group A were lower than those in the group B and group C （P〈0.05）, and the total serum bilirubin had an obvious positive correlation with the total serum bile acid,（r=0.763 2）, and the total serum bilirubin, total bile acid and LDL-C had an obvious negative correlation, （r=-0.950 5;r=-0.956 6）. Conclusion The serum bilirubin and total serum bile acid level have a protection effect on the big vessel of T2DM patients, which is of clinical guidance significance to preventing and slowing the deterioration of diabetic macroangiopathy.

关 键 词：2型糖尿病 糖尿病大血管病变 血清胆红素 血清胆汁酸 

分 类 号：R587.1[医药卫生—内分泌]