血清CXCL12和其特异性受体CXCR4在食管癌诊断中的价值  

The Serum Concentrations of Chemokine CXCL12 and Its Specific Receptor CXCR4 in Patients with Esophageal Cancer

作　　者：孙瑶[1] 李乃坤[2] 武金凤[1] 李学波[1] 

机构地区：[1]潍坊市益都中心医院放疗科,山东青州262500 [2]潍坊市益都中心医院医务科,山东青州262500

出　　处：《医学与哲学（B）》2017年第5期41-45,共5页Medicine & Philosophy(B)

摘　　要：为了评估血清中趋化因子CXCL12及其特异性受体CXCR4的浓度水平在食管癌诊断中的作用,对49例食管癌患者,39例健康志愿者进行了研究,检测其血清中CXCL12、CXCR4、癌胚抗原(CEA)、鳞状细胞癌抗原(SCC-Ag)及C-反应蛋白(CRP)的浓度。结果显示同健康对照组相比,食管癌患者血清中CXCL12的水平显著增高,同时其受体CXCR4的表达显著降低。CXCR4的诊断敏感性,阴性预测价值及精准度最高,同经典的肿瘤标志物和C-反应蛋白联合分析,价值更高。特别在结合经典肿瘤标志物检测时血清CXCR4检测可能会改善食管癌的诊断。This study is the first to assess the serum concentration of chemokine CXCL12 and its specific receptor CXCR4 in the diagnosis of EC patients. The present study included 49 patients with EC and 30 healthy volunteers. The serum concentration of CXCL12, CXCR4, carcinoembryonal antigen （CEA）, squamous cell cancer antigen （SCC-Ag） and C- reactive protein （CRP） levels were measured. The results showed that the serum concentrations of CXCL12 were significantly higher, while those of its receptor CXCR4 were significantly lower in EC patients compared to healthy controls. The diagnostic sensitivity, negative predictive value, and accuracy of CXCR4 were the highest among all analyzed proteins and increased for combined analysis with classical tumor markers and CRP levels. Our findings suggest that serum CXCR4 may improve the diagnosis of EC patients, especially in combination with classical tumor markers.

关 键 词：趋化因子 CXCL12 CXCR4 食管癌 

分 类 号：R246.5[医药卫生—针灸推拿学]