基于文献记载的海洋中药方剂用药规律探索  

Exploration on Medication Rules of Chinese Marine Materia Medica Prescriptions based on Literature Recordings

作　　者：张家蔚[1] 杨凯晶 崔赛赛 刘晓彤[1] 陈娇健 李佼阳 于华芸[1] 付先军[2,3,4] 

机构地区：[1]山东中医药大学中医学院,济南250355 [2]山东中医药大学信息管理学院,济南250355 [3]山东中医药大学中医药经典理论教育部重点实验室,济南250355 [4]山东中医药大学中医医史文献学泰山学者工作室,济南250355

出　　处：《世界科学技术-中医药现代化》2017年第3期414-418,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：教育部高等学校博士学科点专项科研基金项目(20123731120001):基于方剂文献文本挖掘和关联网络的海洋中药用药经验模式研究;负责人:付先军;山东中医药大学大学生研究训练计划(2015496):海洋中药方剂数据库的构建和用药经验模式挖掘;负责人:张家蔚;山东省重点研发计划(2016CYJS08A01-1):基于知识云的中医经方信息服务和精准化靶向虚拟筛选研究;负责人:王振国;科学技术部国家高技术研究发展计划"863计划"项目(2013AA093001):海洋传统药源生物资源挖掘整理研究;负责人:王长云

摘　　要：目的:通过整理收集含海洋中药的文献,分析古代文献记载的含海洋中药方剂用药规律,了解海洋中药方剂的概况,为挖掘海洋中药用药规律提供数据支持。方法:以海洋中药的药名为检索词,检索《中华医典》、《中华海洋本草》、《中华本草》、《中国药典》、《中药大辞典》等相关文献,筛选含海洋中药方剂,抽取信息并进行标准化处理,构建数据库,初步分析挖掘含海洋中药方剂的相关信息和用药规律。结果:筛选出16 715首含海洋中药的方剂,包含144 014条数据,涉及海洋中药218味,汤剂是最常见的剂型,明、清两朝代的海洋中药方剂数最多;每首方剂中海洋药物出现频率最高的是1-3味,全部由海洋中药组成的方剂占8.065%,其他的都是与陆地中药进行配伍,其中各占一半的达到7.754%,所有方剂中使用频次最高的海洋中药是牡蛎,海洋中药方剂中最常见的陆地中药是甘草和当归。结论:含海洋中药方剂数量庞大,配伍和临床应用具有一定特色,可以为海洋中药的进一步研发和扩大临床应用提供数据基础。Through the literature collection on Chinese marine materia medica, this study analyzed medication rules of Chinese marine materia medica prescription, understood general conditions of Chinese marine materia medica prescription, in order to conduct data mining on medication rules of Chinese marine materia medica prescription. The name of Chinese marine materia medica was used as the search term. Chinese marine materia medica prescriptions were searched in related literatures of Chinese Medicine Code, Chinese Marine Materia Medica, Chinese Materia Medica, Chinese Pharmacopoeia and Great Dictionary of Chinese Medicine. The information was extracted and standardized to construct database for the initial data mining of related information and medication rules of Chinese marine materia medica prescriptions. The results showed that 16715 Chinese marine materia medica prescriptions were screened, which contained 144014 items of data, involving 218 kinds of Chinese marine materia medica. Decoction was the most common dosage form. The amount of Chinese marine materia medica prescription in the Ming and Qing dynasties was the largest. The highest frequency of Chinese marine materia medica in one prescription was 1 to 3 types. The prescription composed all by Chinese marine materia medica occupied 8.065%. Other prescriptions contained the compatibility of Chinese terrestrial materia medica. The prescription containing materia medica half from the sea and half from the land, occupied 7.754%. The Chinese marine materia medica used with the highest frequency in all prescriptions was oyster. The frequently used Chinese terrestrial materia medica was licorice and angelica in Chinese marine materia medica prescriptions. It was concluded that the number of Chinese marine materia medica prescription was large. Its compatibility and clinical application had a certain characteristic, which provided data foundation for the further research and development of Chinese marine materia medica.

关 键 词：海洋中药 含海洋中药方剂 中医文献 数据挖掘 

分 类 号：R282.77[医药卫生—中药学]