2-(3,4-二氯苯基)-4-氟苯胺的合成工艺研究  

Synthesis of 2-(3,4-Dichlorophenyl)-4-fluoroaniline

作　　者：薛亮[1,2,3] 杜升华[2,3] 王宇[2,3] 马保德[2,3] 尹笃林[1] 

机构地区：[1]湖南师范大学,湖南长沙410006 [2]湖南化工研究院有限公司国家农药创制工程技术研究中心,湖南长沙410014 [3]农用化学品湖南省重点实验室,湖南长沙410014

出　　处：《精细化工中间体》2017年第2期29-31,54,共4页Fine Chemical Intermediates

基　　金：国家自然科学基金(22272062)

摘　　要：以对氟苯胺为起始原料,经过乙酰化、溴化得到2-溴-4-氟乙酰苯胺,与3,4-二氯苯硼酸通过Suzuki偶联并脱去乙酰基得到2-(3,4-二氯苯基)-4-氟苯胺。并对反应条件进行了优化,目标总收率为66.3%,其结构经MS,1H NMR确证。In this paper, 2-bromo-4-fluoroacetanilide was obtained by acetylation and brominated using 4- fluoroaniline as the starting material. Then this obtained intermediate reacted with 3,4-dichlorophenylboronic by Suzuki coupling followed by deacetylation using thionyl chloride to give 2-（3,4-dichlorophenyl）-4-fluoroaniline. The reaction conditions were studied and the total yield was up to 66.3%. The structure was confirmed by MS and 1H NMR.

关 键 词：联苯吡菌胺 SUZUKI偶联 2-(3  4-二氯苯基)-4氟苯胺 

分 类 号：S482.2[农业科学—农药学]