重庆市非酒精性脂肪性肝病中医证型规律及特点的研究  

Research on TCM syndrome rule and characteristics of non-alcoholic fatty liver disease in Chongqing City

作　　者：宋翊[1] 廖宇[1] 严君[1] 李国俊 李林峰[3] 赵晓春 万颖[1] 邓先勇 刘华宝[1] 罗登旭 

机构地区：[1]重庆市中医院肝病科,400021 [2]重庆市永川区中医院风湿科,402160 [3]重庆市涪陵区中医院脾胃科,408000 [4]重庆市三峡中心医院感染科,404000 [5]成都关怀医院中医科,610000 [6]重庆市黔江区中医院感染科,409000

出　　处：《重庆医学》2017年第18期2529-2531,共3页Chongqing medicine

基　　金：重庆市卫生和计划生育委员会中医药科技项目(zy201402048)

摘　　要：目的探讨非酒精性脂肪性肝病(NAFLD))中医证型分布规律及其与相关临床指标的相关性。方法调查重庆市1 950例NAFLD患者一般情况、中医四诊、生化及CT结果,分析中医证型分布规律及其与生化、CT的相关性。结果 1 950例患者中,湿热蕴结、湿浊内停、肝郁脾虚、痰瘀互结、肝肾阴虚证分别占36.62%、27.69%、19.38%、10.10%、6.21%;不同证型的年龄差异有统计学意义(P<0.05);重度脂肪肝肝肾阴虚证(35.54%)最多,其次为痰瘀互结证(15.23%);湿热蕴结证丙氨酸转氨酶(ALT)、天冬氨酸氨基转移酶(AST)水平较高;肝肾阴虚证空腹血糖(FBG)水平较高;肝郁脾虚证总胆固醇(TC)、三酰甘油(TG)、FBG水平较低,差异有统计学意义(P<0.05)。结论 NAFLD患者以湿热蕴结证分布最多,肝肾阴虚证重度脂肪肝比例最高,不同辩证分型可能对临床指标及疾病转归有重要作用。Objective To investigate the traditional Chinese medicine（TCM） syndromes distribution rule of nonalcoholic fatty liver disease（NAFLD） and its correlation with related clinical indexes. Methods The general condition,TCM four diagnostic methods,biochemical and CT results in 1950 cases of NAFLD in Chongqing City were investigated for analyzing the TCM syndromes distribution rule and its correlation with biochemistry and CT. Results In 1950 cases, the accumulation and binding of damp-heat, congestion of dampness turbidity, stagnation of liver-QI with spleen deficiency, intermin-gled phlegm and blood stasis and yin deficiency of both liver and kidney accounted for 36.62 %, 27.69 %, 19.38 %, 10.10 % and 6.21 % respectively% there was statistically significant difference in age among different TCM syndromes（P〈0.05）;the vin deficiency syndrome of both liver and kidney and intermin-gled phlegm and blood stasis in severe fatty liver were maximal;glutamic-pyruvic transaminase（ALT） and glutamic-oxalacetic transaminase（AST） level was higher in the accumulation and binding of damp-heat; the level of fasting plasma glucose（FBG） was higher in the yin deficiency syndrome of both liver and kidney; the total cholesterol（TC）, triglyceride（TG） and FBG levels were lower in the stagnation of liver-QI with spleen deficiency, the differences were statistically significant（P〈0.05）. Conclusion In NAFLD patients,the accumulation and binding of damp-heat distribution is maximal, the proportion of severe fatty liver with vin deficiency syndrome of both liver and kidney is higher. Different dialectical types may play an important role in the clinical indexes and disease development.

关 键 词：非酒精性脂肪性肝病 中医证型 客观指标 流行病学 

分 类 号：R259[医药卫生—中西医结合]