清热解毒活血法对不稳定型心绞痛患者内皮功能的影响  

Effect of Qingre Jiedu Huoxue Method on Endothelial Function in Patients with Unstable Angina

作　　者：刘景 马哲河 马红 

机构地区：[1]广东省广州市海珠区中医医院,广东广州510220

出　　处：《中国中医急症》2017年第6期1064-1066,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：广东省中医药管理局科研项目(20131011)

摘　　要：目的观察清热解毒活血法对不稳定型心绞痛(热毒血瘀证)患者内皮功能的影响。方法将80例患者按随机数字表法分为对照组(常规西药治疗)和治疗组(常规西药治疗基础上加用清热解毒活血方),各40例,治疗周期为4周。主要观察两组治疗前后心绞痛发作、内皮功能的变化。结果对照组与治疗组心绞痛缓解总有效率分别为75.00%和92.50%,差异有统计学意义(P<0.05);治疗后,两组患者血浆内皮素-1(ET-l)、血管性血友病因子(v WF)均降低,一氧化氮(NO)均升高(P<0.05),且组间差异有统计学意义(P<0.05)。结论清热解毒活血法能有效改善不稳定型心绞痛(热毒血瘀证)的血管内皮功能和临床症状,是安全、有效的辅助治疗方法。Objective： To investigate the effect of Qingre Jiedu Huoxue method on endothelial function in pa-tients with unstable angina. Methods： 80 cases with UA and toxic heat and blood stasis syndrome were randomly divided into the control group （treated by routine Western medicine） and the treatment group （treated by Qingre Jiedu Huoxue decoction on basis of routine treatment）. The course lasted for four weeks. Angina pectoris attacks and the changes of endothelial function were observed before and after treatment in the two groups. Results： The total effective rate of angina pectoris relief in the control group and the treatment group was 75%and 92.50%,re-spectively,and there was a significant difference between them （P〈0.05）. After treatment,ET-l and vWF in the two groups decreased,and NO increased （P〈0.05）,and there was a significant difference between them （P〈0.05）. Conclusion： Qingre Jiedu Huoxue method can improve endothelial function and symptoms in patients with UA and toxic heat and blood stasis syndrome,safe and effective as adjuvant drug.

关 键 词：不稳定型心绞痛 血管内皮功能 清热解毒活血 

分 类 号：R541.4[医药卫生—心血管疾病]