疏肝滋肾法对女性骨关节病患者激素水平及炎症因子的影响  

Effect of Shugan Zishen Method on Patients with Arthritis Hormone Levels and Inflammatory Factors in Women's Bone

作　　者：薄云[1] 李淑贤[1] 赵丽艳[1] 王振宏[2] 王春英[2] 李红[3] 耿海霞[4] 

机构地区：[1]唐山市丰润区第二人民医院中医科,河北唐山063004 [2]唐山市丰润区人民医院,河北唐山063000 [3]唐山市中医院,河北唐山063000 [4]唐山市丰南区中医院,河北唐山063000

出　　处：《辽宁中医杂志》2017年第6期1193-1195,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2014273)

摘　　要：目的:探讨疏肝滋肾法对女性骨关节病患者激素水平及炎症因子的影响。方法:将76例女性骨关节病患者分为两组,每组38例。对照组采用西医常规治疗。研究组采用疏肝滋肾法治疗。于治疗前后对比两组症状评分、视觉模拟评分法(VAS)评分、关节骨性关节炎严重性指数(ISOA)评分及血清雌激素(E_2)、孕酮(T)、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)的变化。结果:研究组的疗效显著优于对照组,差异有统计学意义(P<0.05);两组治疗后症状评分、VAS评分、ISOA评分均显著降低(P<0.05);治疗后,研究组症状评分、VAS评分、ISOA评分显著低于对照组,差异有统计学意义(P<0.05);两组治疗后E_2、T显著升高,TNF-α、IL-1β显著降低(P<0.05);治疗后,研究组E_2、T显著高于对照组,TNF-α、IL-1β显著低于对照组,差异有统计学意义(P<0.05)。结论:疏肝滋肾法对女性骨关节病的疗效确切,能显著改善患者临床症状,减轻关节疼痛,提高雌激素水平,减轻炎症反应。Objective： To investigate the effects of Shugan Zishen method on hormone levels and inflammatory factors in women＇s bone. Methods：Seventy- six cases of female patients with bone and joint disease were divided into two groups ,38 cases in each group. The control group was treated with routine western medicine. The research group was treated by Shugan Zishen method. Before and after treatment,the changes of symptom score, VAS score, ISOA score and serum E2,T,TNF - α and IL - 1β were compared between the two groups. Results：The efficacy of the study group was significantly better than that of the control group. The difference was statistically significant （ P 〈 0. 05 ）. After treatment, the symptom score, VAS score and ISOA score were significantly lower in the two groups （ P 〈 0.05 ）. After treatment, the symptom score, VAS score and ISOA score of the study group were significantly lower than those of the control group. The difference was statistically significant （ P 〈 0. 05 ）. E2 and T were significantly increased after treatment in two groups and TNF - α and IL - 1β were significantly decreased （ P 〈 0.05 ）. After treatment, the study group＇s T and E2 were significantly higher than those of the control group. TNF - α and IL - 1β were signifi-cantly lower than those of the control group. The difference was statistically significant （ P 〈 0. 05 ）. Conclusion ： The curative effect of Shugan Zishen method on female bone joint disease is effective. The method can significantly improve the clinical symptoms, re- lieve joint pain,improve the level of estrogen and reduce inflammation.

关 键 词：疏肝滋肾法 女性骨关节病 E2 T TNF-Α IL-1Β 

分 类 号：R684[医药卫生—骨科学]