阿坝地区结核病患者对抗结核药物治疗的依从性  

Adherence to anti-tuberculosis treatment among tuberculosis patients in Aba prefecture

作　　者：李永富[1] 幸晓琼 邱东鹰[2] 

机构地区：[1]阿坝藏族羌族自治州人民医院药剂科,阿坝624000 [2]复旦大学附属中山医院老年病科,上海200032

出　　处：《中国临床药学杂志》2017年第3期162-168,共7页Chinese Journal of Clinical Pharmacy

基　　金：阿坝藏族羌族自治州科技局阿坝州2016年第一批应用技术研究与开发资金支持

摘　　要：目的研究阿坝地区结核病患者对抗结核治疗药物依从性,并探讨与服药依从性差相关的危险因素。方法采用横断面研究方法,共采访204例接受抗结核药物治疗的结核病患者,使用问卷调查方式来评估药物治疗依从性。患者服用抗结核治疗药物的剂量占医师处方剂量的百分比低于90%为依从性差。运用Logistic回归模型判定服药依从性差的危险因素。结果在所有接受抗结核治疗患者中服药依从性差的患者占21.1%。抗结核治疗服药依从性差的预测因素为复治患者和结核病知识缺乏的患者,如不知道结核病是如何传播、不知道抗结核药物的不良反应和不知道符合结核病治疗的日常饮食。结论本研究显示阿坝地区相对较低的抗结核治疗服药依从性,这需要更详尽的随访计划并努力促进患者健康教育,以提高阿坝地区抗结核治疗药物依从性。AIM To assess treatment adherence and to identify risk factors associated with non-adherence in tuberculosis （TB） patients in Aba prefecture. METHODS In this cross-sectional study, 204 participants who were taking anti-TB drug for treatment were interviewed using a questionnaire to evaluate treatment adherence. TB medication non-adherence was defined as having taken less than 90% of the anti-TB drugs. Risk factors for non-ad- herence were identified using a logistic regression model. RESULTS Overall proportion of non-adherence with anti-TB treatment was 21. 1%. Significant predictors of non-adherence were being re-treatment cases and lack of TB knowledge such as those who didn＇ t know how TB spread, the adverse reactions of anti-TB drugs and the diet to comply with the treatment. CONCLUSION In the present study area, there is a relatively low level of adherence to anti-TB treatment in Aba prefecture. Further effort like more detailed follow-up plan and health education to patients or family are needed to reduce those factors which affect adherence in order to improve the adherence to anti-TB treatment in the present study area.

关 键 词：结核病 依从性 抗结核治疗 

分 类 号：R52[医药卫生—内科学]