瓜馥木抗肿瘤活性研究  

The Antitumor Activity of Fissistigma oldhamii(Hems1.)Merr.

作　　者：曾立[1] 向荣[1] 傅春燕[1] 

机构地区：[1]邵阳学院药学系,湖南邵阳422000

出　　处：《广东化工》2017年第11期55-56,69,共3页Guangdong Chemical Industry

基　　金：湖南省科技厅科研项目(2014SK3030);湖南省中医药科研计划项目(2013142)

摘　　要：目的研究瓜馥木和黄酮化合物抗肿瘤活性。方法以半数抑制浓度(IC50)为评价抗肿瘤活性强度的指标,采用MTT法测定瓜馥木提取物和黄酮化合物体外抗肿瘤活性。结果 5,6,7,8-四甲氧基黄酮、石油醚、氯仿和乙酸乙酯的提取物均能显著抑制SPCA-1肺腺癌细胞、SGC-7901胃癌细胞、BEL-7402肝癌细胞和K562白血病细胞增殖;水提取物只对K562白血病细胞有抑制作用。结论瓜馥木具有抗肿瘤活性。Objective To study the antitumor activity ofFissistigma oldhamii（Hemsl.）Merr and flavonoid compounds. Methods MTT assay was employed to test the antitumor effect ofFissistigma oldhamii（Hems 1 .）Merr, with IC50 applied to evaluate the degree of antitumor activity. Results 5, 6, 7, 8-tetramethoxyflavone, the acetate of petroleum ether, chloroform and ethyl can significantly inhibit SPCA-1 lung adenocarcinoma cells, SGC-7901 gastric cancer cells, BEL-7402 hepatoma cells and K562 Leukemia cell proliferation; the extract of water only have inhibitory effect on K562 leukemia cells. Conclusion Fissistigma oldhamii（Hemsl.）Merr has antitumor activity.

关 键 词：瓜馥木 MTT法 抗肿瘤活性 

分 类 号：R284.2[医药卫生—中药学]